Professor of Cancer Biology; Deputy Centre Lead
My research is focused on the links between cancer and inflammation, being especially interested in translating knowledge of cancer biology into new biological treatments for cancer and in the role that inflammatory cytokines play in cancer promotion. I study the links between cancer and inflammation and research ways of translating this to clinical trial.
Centre for Tumour Microenvironment
Lecturer
My lab aims to understand the basic mechanisms controlling DNA replication in mammalian cells and how disruption of this process leads to genomic instability and cancer.
Centre for Cancer Cell and Molecular Biology
Senior Lecturer in Molecular Oncology
My research aims to reveal how cancer cells evolve to proliferate and evade cell death in order to develop new therapeutic strategies, in particular for the treatment of breast cancer. I am interested in understanding the contribution of cellular metabolism to cancer cell survival and proliferation.
Reader in Genome Regulation
Our group is interested in epigenetic regulation of somatic mutagenesis in normal and malignant B cells. Specifically, we aim to understand how alterations in the nuclear envelope influence B cell chromatin conformation, and what the epigenetic consequences of these alterations are.
Centre for Haemato-Oncology
Senior Lecturer in Tumour Biology
Protein kinases represent the largest group of drug targets in cancer therapy. My research focuses on kinases regulating cancer cell growth and motility to understand how and when to target them with drugs.
Centre for Tumour Biology
Professor of Bioinformatics; Deputy Centre Lead, Centre for Cancer Biomarkers and Biotherapeutics
My research interests lie in the area of translational bioinformatics. Current research projects are focused in high-throughput data analysis, integration with clinical data, databases and software development, particularly for pancreatic cancer and breast cancer.
Centre for Cancer Biomarkers & Biotherapeutics (BCI); Centre for Computational Biology
Professor of Molecular Pathology and Biomarkers
My research focuses on molecular pathology of pancreatic cancer, in particular its development and progression. We are using this knowledge to develop biomarkers for early, non-invasive detection of this malignancy in urine specimens.
Centre for Cancer Biomarkers & Biotherapeutics
Professor of Cell Signalling and Proteomics
My research group uses unique proteomics and computational approaches to understand how cell signalling pathways driven by the activity of protein kinases contribute to the development of cancer. Increasing this knowledge will be invaluable in advancing personalised cancer therapies.
Centre for Cancer Genomics & Computational Biology
Reader in Haemato-oncology, Honorary Consultant
My group works on developing novel approaches to improve efficacy and safety of allogeneic stem cell transplantation and adoptive immunotherapy as treatments for blood cancers. We focus on T-cell alloreactivity in the context of stem cell transplantation and immunotherapy.
We are interested in understanding the cellular and molecular mechanisms that promote cancer cell plasticity and adaptation of tumour cells in metastatic niches and under therapeutic pressure.
Senior Lecturer
My group aims to discover the epigenetic changes taking place during cancer initiation and develop potential drugs that can prevent these changes which may be abnormal but reversible, before many damaging mutations occur.
Our group studies changes in metabolism and metabolic stresses that are caused by oncogene activation and how these stresses lead to tumour suppressive responses. We hope that by understanding these processes, we will reveal nodes of metabolic regulation that can be targeted to develop new cancer therapies.
Professor of Personalised Cancer Medicine; Centre Lead, Centre for Cancer Genomics and Computational Biology
My research group works on molecular pathology, genetics and progression of leukaemia and lymphomas, aiming to improve on current diagnostic, prognostic and treatment strategies.
Clinical Senior Lecturer in Haemato-Oncology
My research interests focus on mechanisms of disease initiation and maintenance and the identification and validation of novel therapeutic targets in myeloid leukaemias.
Our goal is to identify mechanisms that support haematopoietic stem cell function and understand how the leukaemic stem cells 'play' with these mechanisms to thrive.
Reader in Cancer Cell Biology
Our research group focuses on understanding how centrosome amplification impacts tumour progression and how we can target cells with amplified centrosomes to develop new cancer therapies.
Professor of Cancer Evolution; Deputy Centre Lead, Centre for Cancer Genomics and Computational Biology
My lab measures the patterns of clonal evolution that define carcinogenesis and develops novel mathematical tools for analysis and prediction. By characterising tumour evolution, we aim to find better ways to determine prognosis and more effective ways to treat cancers.
Professor of Medical Oncology; Centre Lead, Centre for Haemato-Oncology
My primary research interests include the immunotherapy of cancer (including stem cell transplantation), the identification of B-cell-tumour antigens, and the detection and treatment of minimal residual disease in leukaemia and lymphoma.
Professor of Cancer Cell Biology; Deputy Centre Lead, Centre for Tumour Biology
We are interested in how cancer cells interact with each other and the microenvironment. We investigate how cancer cells develop resistance to therapies and design drug combination approaches to overcome this.
Reader in Cancer Gene Therapy
The research in our team is focused on the development of novel treatment strategies to target prostate cancers and pancreatic cancers using genetically modified viruses that target, replicate and kill cancer cells (replication-selective oncolytic viruses) but leave normal cells unharmed.
Centre for Cancer Biomarkers and Biotherapeutics
Professor of the Tumour Microenvironment; Deputy Institute Director, Barts Cancer Institute; Centre Lead, Centre for Tumour Microenvironment
We examine molecular mechanisms underlying tumour stromal contributions to tumour growth and therapy efficacy. In particular, angiogenesis (the formation of new blood vessels) and the cancer associated fibroblasts roles, using a combination of cell type-specific knockout and knockin systems in mouse models of cancer and analysis of the cellular and molecular mechanisms behind these observations.
My lab focuses on discovering functions of phosphorylation induced by damaged DNA in normal and cancer cells, and investigating the role of different phosphorylation events in cancer development.
Professor of Breast Pathology
My research in breast cancer focuses on the progression of in situ to invasive disease, with the aims of identifying 1) markers which can predict behaviour and 2) novel therapeutic targets.
Our group focuses on understanding the molecular and cellular mechanisms that mediate resistance to anti-cancer therapies in breast cancer. Using state-of-the-art mouse models of cancer, as well as quantitative molecular and cellular approaches, we are interested in dissecting the microenvironmental cues that orchestrate specific tumour responses and metastasis formation.
Reader in Cellular Oncology
We study the role of growth factor receptor signalling and intracellular trafficking (movement inside cells) in tumour growth and metastasis in the view of improving cancer therapy.
Professor of Liver and Pancreas Surgery
I am a surgeon-scientist. My clinical research interests include tissue banking, clinical trials, innovative surgical techniques, epidemiology, meta-analysis and patient care pathways. My translational research interests include pancreatic cancer stroma and tumour-stroma cross-talk including cell signalling, adhesion, metastasis, invasion, leading to innovative therapies and novel biomarkers.
Clinical Professor of Haematology; Deputy Centre Lead, Centre for Haemato-Oncology
Our research aims to understand the biology of leukaemia stem cells and identify the mechanisms they use to escape treatments.
My studies concentrate on the immunogenetics of human B cell malignancies, such as chronic lymphocytic leukaemia, follicular lymphoma and the role for B cell receptor in the development of B cell lymphoma and leukaemia
Clinical Reader
I am an Honorary Consultant at Barts Health NHS Trust where I have a lymphoma practice. Since joining Barts, I have taken an active interest in clinical trials and joined the NCRI Hodgkins Lymphoma subgroup. I speak at the Lymphoma Action Management Course on relapsed Hodgkin's lymphoma.
Professor of Molecular Oncology; Director, Barts Cancer Institute; Centre Lead, Centre for Cancer Biomarkers and Biotherapeutics
My groups' primary research interests are in the genomics and molecular pathology of pancreatic cancer and the development of oncolytic virotherapy. We use global profiling approaches at the genomic and proteomic levels to identify targets that can be exploited for detection and treatment of this disease.
Reader in Medical Oncology; Honorary Consultant; Deputy Centre Lead, Centre for Cancer Cell and Molecular Biology
Our lab aims to improve treatments for women with ovarian cancer, particularly those that are resistant to chemotherapy. We are interested in developing therapies that can adapt to the evolution of chemotherapy resistance over time.
Professor of Molecular Oncology
We aim to identify genetic alterations that influence cancer development, progression and therapeutic responses, in particular for prostate cancer, and further develop them into biomarkers for cancer diagnosis and therapeutic stratification, with a current focus on circulating biomarkers.
My lab utilises state-of-art multi-omics methodologies to study how protein synthesis is dysregulated in cancer cells, and how this dysregulation contributes to various stages of cancer progression.
Professor of Tumour Biology; Centre Lead, Centre for Tumour Biology
I study the biology of tumour invasion with a particular interest in the roles of the adhesion molecules expressed on the cell surface that mediate this process. Our group concentrates on the study of integrins that are the principal family of adhesion molecules that mediate interaction between cells and the extracellular matrix (ECM).
Reader in Cancer Cell Biology; Deputy Centre Lead, Centre for Cancer Cell and Molecular Biology
Our research is based on exploiting DNA repair defects in cancer for the identification of new personalised therapies. We use compound and siRNA screening to identify new therapeutics for tumours based on their specific DNA repair status.
My lab aims to understand the mechanisms that underlie numerical and structural chromosome aberrations in cancer at a molecular level, which also involves understanding how normal cells replicate and segregate their genomes.
Reader in Gastrointestinal Biology
Our research focuses on stem cell niches and clonal expansion in Barrett's oesophagus, stomach and breast cancer.
Clinical Senior Lecturer
My research focuses on understanding the genetic and molecular mechanisms that underlie the initiation and progression of B-cell non-Hodgkin's lymphomas in order to define clinically-relevant biomarkers.
My group studies how different populations of immune cells in the tumour microenvironment cross-talk in order to establish a "favourable" niche in metastasis.
The focus of our research is the tumour microenvironment (TME). We are particularly interested in understanding the composition and function of the tumour extracellular matrix in immunosuppression.
My lab aims to understand the alterations in metabolism that take place in cancer and investigate whether extrinsic factors, such as diet, influence cancer metabolism and disease trajectory. We then want to uncover whether these dependencies can be exploited therapeutically.
Professor of Genitourinary Oncology
My main research interests are in genital and urinary cancers, and I lead a spectrum of clinical studies from phase I to randomised phase III. The majority of the studies are translational phase II studies investigating novel targeted and immune therapies.
Centre for Experimental Cancer Medicine
My focus is on detailed translational trials in pancreatic cancer, with a focus on targeting the tumour microenvironment. Our aim is to define what perturbations occur in tumours of patients receiving trial drugs.
Clinical Senior Lecturer in Urology
My laboratory research explores alternative pre-mRNA splicing in prostate cancer (PCa) biology, and liquid biopsy-derived molecular biomarkers of treatment outcomes. My clinical research investigates chemo-preventative strategies to reduce low risk PCa progression, and surgical alternatives to cytotoxic chemotherapy for metastatic testicular cancer.
Our research group is interested in uncovering the molecular mechanisms regulating tissue growth, invasion, metastasis and tumour heterogeneity using the fruit fly Drosophila melanogaster as a genetically tractable model organism.
My major research interest is understanding the metabolism of chronic lymphocytic leukaemia and lymphoma with the aim that this will underpin the development of the next generation of anti-metabolic drugs for these diseases.
My main research interests are in haematopoietic stem cells and leukemic initiating cells. I seek to understand how intrinsic and extrinsic signals are integrated by normal and malignant stem cells.
Professor of Cancer Cell Biology
Our research focuses on how the cytoskeleton of cancer cells regulates transcriptional rewiring during tumour growth and dissemination. We aim to understand how such rewiring affects the tumour microenvironment.
Professor of Cancer Medicine; Centre Lead, Centre for Experimental Cancer Medicine
My research interests focus on improving the care of women with breast cancer through clinical trials. I lead a spectrum of clinical studies spanning the spectrum of the disease and ranging from phase I to randomised phase III. The majority of these studies are translational phase II studies investigating novel targeted and immune therapies.
Professor of Cellular and Molecular Biology; Centre Lead, Centre for Cancer Cell and Molecular Biology
My group's work focuses on the role of the tumour suppressor protein LIMD1 and its family members Ajuba and WTIP and how their deregulation in normal tissue contributes to the development of lung, renal and breast cancer.
My research focuses on kinase biology and how kinase signalling pathways are hijacked in cancer. We combine computational biology with proteomics and cell biology to uncover novel ways to target these dysregulated networks.
Reader in Preclinical Molecular Imaging
My main interests are in radiopharmaceutical development and the use of pre-clinical molecular imaging in drug development, especially biopharmaceuticals.
My group studies how RNA-mediated mechanisms, in particular long noncoding RNAs, regulate cell division and how dysregulation of these processes leads to genome instability and cancer.
Professor of Medical Oncology
My main research interest is in exploring why ASS1 is aberrantly expressed in human cancers and how this knowledge may be exploited for anticancer therapy. I lead an active translational programme from bench to bedside of the arginine-depleting agent ADI-PEG20 in several hard-to-treat cancers including the ADAM, TRAP and ATOMIC clinical studies.
My main research interests lie in applying bioinformatics and computational approaches to analyse large-scale cancer datasets to uncover novel diagnostic and prognostic features. I also lead the Cancer Research UK Barts Centre Bioinformatics Core Facility.
Professor of Cancer Cell and Gene Therapy
We work on cancer prevention and immunotherapy using tumour-targeted replicating oncolytic viruses, in particular focusing on replicating adenovirus and vaccinia virus.
My group combines mathematics, computer simulations and genomic information to study evolutionary processes. We aim to understand how a tumour's evolutionary history is reflected in its genome, how evolution can be quantified in individual tumours and how this information predicts future evolution.
My research focuses on the fundamental aspects of leukaemia initiating cell biology in adult acute lymphoblastic leukaemia, with the aim of revealing dependencies that are tractable targets for therapy.