Profile
Organiser, Stem Cell Initiative
Summary
Recent and ongoing research projects:
- Cancer stem cells.
- Epithelial mesenchymal transition
- Hypoxia
- CD44 function
Teaching
Problem Based Learning and FunMed
Topics for PhD supervision:
Cancer stem cells
Research
Research Interests:
Cancer, stem cells, differentiation, hypoxia.
Publications
Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Biddle A, Liang X, Gammon L, Fazil B, Harper LJ, Emich H, Costea DE, Mackenzie IC. Cancer Res. 2011 Aug 1;71(15):5317-26.
Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance. Harper LJ, Costea DE, Gammon L, Fazil B, Biddle A, Mackenzie IC. BMC Cancer. 2010 Apr 28;10:166.
Epithelial stem cells and malignancy. Costea DE, Gammon L, Kitajima K, Harper L, Mackenzie IC. J Anat. 2008 Jul;213(1):45-51.
Stem cell patterns in cell lines derived from head and neck squamous cell carcinoma. Harper LJ, Piper K, Common J, Fortune F, Mackenzie IC. J Oral Pathol Med. 2007 Nov;36(10):594-603.
Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines. Locke M, Heywood M, Fawell S, Mackenzie IC. Cancer Res. 2005 Oct 1;65(19):8944-50.
View all Ian Mackenzie's Research Publications at: http://www.researchpublications.qmul.ac.uk
