Mr Mohamed Thaha, MBBS, PhD, FRCS (Gen Surg), PG Cert Health Economics

Profile

Mo Thaha graduated in 1994 from University of Kerala, India and trained as a Colorectal and Laparoscopic surgeon in Ninewells Hospital & Medical School, University of Dundee, Scotland, where he held the Clinical Lectureship (SHEFC) in Surgery (2003 - 2010) mentored by Professor Robert JC Steele.  He held the prestigious NES/CSO Scotland research training fellowship and completed a substantial body of clinical research, including running the largest RCT on haemorrhoidal disease evaluating the role of stapled anopexy.  He was awarded a PhD in 2010 by University of Dundee.  In March 2010, he joined Queen Mary University of London as Professor Norman S Williams 'Senior Colorectal fellow' and was subsequently appointed as Senior Lecturer in Colorectal Surgery in August 2011.  He holds an Honorary Consultant appointment in Colorectal Surgery at Barts Health Trust.  His current clinical practice is predominantly Colorectal Oncological surgery and he is pursuing his interest in surgical treatment for recurrent rectal/pelvic cancer incorporating total anorectal reconstruction.

Summary

Recent and ongoing research projects: 

In partnership with Professor Andrew Silver, Colorectal Cancer Genetics Group, Blizard Institute, Mo Thaha is developing a portfolio of translational research investigating potential biomarkers in primary and recurrent colorectal cancers to stratify risk and to predict response of tumours to neoadjuvant therapy.  Mo Thaha and the CCGG are actively collaborating with HPV-related disease interested clinicians and are investigating potential biomarkers of progression of AIN to anal squamous cell carcinoma.


Collaborating with Professor NS Williams, Mo Thaha is currently developing a programme of clinical research on prevention strategies of parastomal hernia and is now recruiting for the RCT investigating the clinical and economic efficacy of a novel surgical technique (SMART) to prevent parastomal hernia.

Teaching

Research

Research Interests:

• Identification of novel biomarkers to stratify prognosis and response to treatment for primary and recurrent rectal cancer
• Identification of biomarkers to predict progression of pre-malignant lesions into invasive anal cancer in normal and high risk patients
• Prevention of parastomal hernia: Clinical trial of a new technique and molecular markers to quantify muscle damage
• Exploiting anterior perineal plane for ultra-low rectal resection in open and laparoscopic surgery (surgical technique, efficacy, safety and quality of life)

Publications

Thaha MA, Campbell KL, Kazmi SA, Irvine LA, Khalil A, Binnie NR, Hendry WS, Walker A, Staines HJ, Steele RJC Prospective randomized multi-centre trial comparing the clinical efficacy, safety and patient acceptability of circular stapled anopexy with closed diathermy haemorrhoidectomy Gut. 2009; Vol. 58 (5): pp668-78

Shanmugam V, Thaha MA, Rabindranath KS, Campbell KL, Steele RJC, Loudon MA Rubber band ligation versus excisional haemorrhoidectomy for haemorrhoids (Review) Cochrane Database of Syst Rev. 2005: Jul 20; (3):CD005034. DOI: 10.1002/14651858.CD005034.pub2.

Ahmed S, Leslie A, Thaha MA, Carey FA, Steele RJC Lower gastrointestinal symptoms do not discriminate for colorectal neoplasia in a faecal occult blood screen-positive population Br J Surg. 2005; Vol. 92 (4): pp 478-81

View all Mohamed Thaha's Research Publications at: http://www.researchpublications.qmul.ac.uk