Dr Xuenong Bo, MB, MSc, PhD

Profile

Xuenong Bo was awarded a Bachelor of Medicine and a MSc in Pharmacology in China. He joined the Department of Anatomy and Developmental Biology in University College London (UCL) as a Visiting Scientist in 1987 and was awarded a PhD in Neurobiology in 1992, supervised by Professor Geoffrey Burnstock (FRS). He continued to work as a Research Fellow and then a Senior Research Fellow in UCL. He also worked as a Visiting Fellow in the lab of Professor Eric Barnard (FRS) in the MRC Laboratory of Molecular Biology in Cambridge for two years. From 1995 to 2001 he mainly carried out his lab work in the Wellcome Laboratory for Molecular Pharmacology in UCL. In 2001 he joined the Institute of Molecular Physiology in the University of Sheffield, headed by Professor Alan North (FRS). In 2002 he was appointed as a Non-Clinical Lecturer in the Department of Neurosurgery in Barts and the London School of Medicine and Dentistry, and promoted to Senior Lecturer in 2008. He was made a Guest Professor of the Third Military Medical University, China.

Teaching

Research

Research Interests:

Before joining Queen Mary University of London (QMUL), his main research interest was on the characterization and molecular cloning of ATP receptors. After the appointment in QMUL, he shifted his research focus to promoting axonal regeneration of injured neurons using gene-targeting techniques. The strategies used include targeting the signalling pathways of axon growth inhibitors, modifying the CNS environment by viral vector-mediated expression of polysialic acid, transplanting genetically modified Schwann cells into the injured CNS. He also studied the involvement of extracellular ATP and its receptors in nerve injury and repair. In recent years he studied the involvement of colony stimulating factor-1 and its receptor in neuronal death in an animal model of multiple sclerosis, in neuropathic pain, and in conditioning effect on axonal regeneration.

Publications

Key Publications

Wu D, Lee S, Luo J, Xia H, Gushchina S, Richardson PM, Yeh J, Krügel U, Franke H,  Zhang Y, Bo X.(2018). Intraneural injection of ATP stimulates regeneration of primary sensory axons in the spinal cord. J Neurosci. 38, (6) 1351-1365. Queen Mary Research Online

Gushchina S, Pryce G, Yip P, Wu D, Pallier P, Giovannoni G, Baker D, Bo X, (2018). Increased expression of colony-stimulating factor-1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss. Glia. 66, (10) 2108 – 2125.
Queen Mary Research Online

Zhang Y, Gao F, Wu D, Moshayedi P, Zhang X, Ellamushi H, Yeh J, Priestley JV, Bo X. (2013). Lentiviral mediated expression of a NGF-soluble Nogo receptor 1 fusion protein promotes axonal regeneration. Neurobiol Dis. 58, (10) 270-280.

Wu DS, Yang P, Zhang XY, Luo J, Haque ME, Yeh J, Richardson PM, Zhang Y, Bo X.(2009). Targeting a Dominant Negative Rho Kinase to Neurons Promotes Axonal Outgrowth and Partial Functional Recovery After Rat Rubrospinal Tract Lesion. Mol Ther. 17, (12) 2020-2030.

Zhang Y, Bo X, Schoepfer R, Holtmaat AJDG, Verhaagen J, Emson PC, Lieberman AR, Anderson PN(2005). Growth-associated protein GAP-43 and L1 act synergistically to promote regenerative growth of Purkinje cell axons in vivo. P NATL ACAD SCI USA. 102, (41) 14883-14888.

All Publications