The Core Pathology facility is a UKAS accredited medical laboratory no 8369, HTA licensed and currently processes over 4,000 surgical cases. We have a full team of consultant histopathologists covering all specialities as well as an experienced and efficient team of biomedical scientists. All the biomedical scientists are HCPC registered and participate in CPD activities.
Specialities
- Dermatopathology
- Gastrointestinal
- Hepatobilary
- Endocrine
- Male Genitourinary
- Gynae
- Lung Pathology
- Soft Tissue
- Lympho - reticular
- Breast
- Head and Neck
- Cytology (Non-gynae)
Turnaround times for most cases are 24-48 hours. More complex specimens, and those specimens requiring additional testing, may take longer to produce the final report.
The facility can also carry out sub-specialities through a network of experts which includes:
- frozen sections
- immunohistochemistry
Some additional testing may be carried out by referral UKAS accredited medical laboratories.
We can provide a full or bespoke service, tailored to your histopathology needs.
For further details please contact Pauline Levey and Laura Neal by email at core-pathology@qmul.ac.uk.
The slide scanning service enables researchers to scan whole slides as digital images.
Equipment
The equipment used is a state of the art Hamamatsu whole slide scanner with free software. This can scan a regular histology slide at either x20 or x40 objective lens on a standard light microscope.
Scan time
The scan time varies with tissue size, however, as a rough guide, a 1x1cm piece of tissue at x20 will take under two minutes and x40 will take under four minutes.
Measurement and analysis
Annotation and measurement is possible. However, no analysis software is available.
Website
Further information can be found on the Hamamatsu website.
What you need to bring
Apart from your samples, you will need a memory stick or external hard drive (at least 250mb space per slide scanned is advisable).
Cost
As this service is part of the Core Pathology unit, the upkeep and maintenance of the equipment needs to be covered as we are a self funding department. The prices can be found on our online ordering system, I-Labs. The button below will take you to the relevant site. If you are a internal user then you will be able to log on with your Queen Mary ID; if you are a external user then you will be required to set up an account and I-Labs will issue you with log in details.
Visit the I-Labs site
2013
Acknowledgements
Rubeta N. Matin iet al., p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. J.Exp. Med. 2013 Vol.210 No3 581-603
2012
Authorship
Diana, c. et al., RHBDF2 Mutations Are Associated with Tylosis a Familial Esophageal Cancer Syndrome. The american journal of Human Genetics 90, 340-346, February 10, 2012.
Acknowledgements
Powell, N., et al., The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor Innate Lymphoid Cells. Immunity 37, 674-684, October 19, 2012.
Wolk, M. and Martin, JE., Fetal haemopoiesis marking low-grade urinary bladder cancer. British Journal of Cancer, 26 June 2012; 1-5
J Broad et al., Regional- and agonist- dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists. British Journal of Pharmacology (2012) 167, 763-774.
2011
Authorship
Robert, CD., et al., Inbuilt mechanisms for overcoming functional problems inherent in hepatic microlobular structure. Computational and mathematical methods in medicine. 2011; Article ID 185845
Acknowledgements
Yadirgi G, et al,. Conditional Activation and Bmi1 Expression Regulates Self-Renewal, Apoptosis and Differentiation of Neural Stem/Progenitor Cells In Vitro and In Vivo. Stem Cells 2011;29:700-712
Wolk, M. and Martin, JE., Fetal haemoglobin (HbF) as an immunohistochemical tumour marker in bone marrow and spleen. J. Clin. Pathol. March 2011; 1-2
Presentations and posters
Chua, Y., et al., Oesophageal epithelial ASIC3 is associated with increase in severity of symptoms in patients with gastro-oesophageal reflux disease (GORD). Gut. 2011; 60:A171
William Harvey Day : Robert, CD., et al., Inbuilt mechanisms for overcoming functional problems inherent in hepatic microlobular structure.
2009
Acknowledgements
Fuchs, A., et al., CD46-induced human Tegs enhances B cell responses. Eur J Immunol. 2009 November; 39(11): 3097–3109
Wolk, M., et al., Titrimetric immunohistochemical evaluation of DNA hypomethylation in uterine tumours. J. Clin. Pathol. 2009; 62:1039-1042
2008
Presentations and posters
Timmins, LH., et al., Investigation into the mechanical and cytoskeletal protein inhomogeneity in bovine carotid arteries. Biomedical Engineering Conference at Imperial College London 2008.
2007
Authorship
Bowen, S., et al., The phagocytic capacity of neurons. Eur J Neurosci. 2007 May; 25(10):2947-55
Acknowledgements
Wolk, M., et al., Foetal haemoglobin-blood cells (F-Cells) as a feature of embryonic tumours (Blastomas). British Journal of Cancer. 2007 (97): 1-8
2006
Acknowledgements
Kruidenier, L., et al., Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells. J.Gastro. 2006 January; 1:137-136
Wolk M., et al., Development of fetal haemoglobin-blood cells (F cells) within colorectal tumour tissues. J. Clin. Pathol. 2006; 59:598-602.
Presentations and Posters
Price. KM., Subcellular functional specificity of dynein-dynactin complex subunits – normal distribution and disturbances in neurodegenerative disease. Path. Soc. Jan 2006.
Kumar, P., et al., Angiogenesis and lymphangiogenesis in testicular germ cell tumours (TGCT). Path. Soc. 2006
2005
Authorship
Banerjea, A., Immunogenic Hsp-70 is overexpressed in colorectal cancers with high-degree microstallite instability. Dis. Colon Rectum. 2005; 48:2322-2328
Acknowledgements
Meeson, S., et al., Preliminary findings from tests of a microwave applicator designed to treat Barret’s oesophagus. Phys. Med. Biol. 2005; 50:4553-4566
Presentations and Posters
Parachaney, P., et al., The effect of intrauterine growth restriction on the elasticity of the thoracic aorta in young rats. William Harvey Day, October 2005 and CISM Research Day June 2005.
Price. KM., Subcellular functional specificity of dynein-dynactin complex subunits – normal distribution and disturbances in neurodegenerative disease. William Harvey Day October 2005 and ALS/MND meeting Dublin December 2005.
2004
Authorship
Kelly, P., et al., Responses of small intestinal architecture and function over time to environment factors in a tropical population. Am. J. Trop. Med. Hyg. 2004;70(4):412-419
Acknowledgements
Sanderson, I.I., et al., Age and diet act through distinct isoforms of the class II transactivator gene in mouse intestinal epithelium. Gastroenterology. 2004;127:203-212
Wolk, M., et al., Blood cell with fetal haemoglobin (F-cells) detected by immunohistochemistry as indicators of solid tumours. J. Clin. Pathol. 2004;57:740-745
2003
Authorship
Roger, F., et al., Abnormal expression of pRb, p16, and cyclin D1 in gastric adenocarcinoma and its lymph node metastases: Relationship with pathological features and survival. Hum. Pathol. 2003, December;34(12):1276-82.
1997
Authorship
Nickols, CD., et al., A Closer Look at the mouse mutant ‘gammy’ (gam), a proposed model for human club foot. Neuropathology and Applied Neuropathology 1997
March 2014
The Core Pathology Department is happy to annouce we have a new online ordering system for our research work, called I-Labs. The system allows you to book bench space to carry out immunohistochemistry, time on the sldie scanner and request all other services. The system will generate quotes which you are able to download as PDFs and will help us and yourself to keep track of work flow and expenditure.
The link below will take you to the relevant site. If you are a internal user then you will be able to log on with your QMUL ID; if you are a external user then you will be required to set up an account and I-Labs will issue you with log in details.
I-Labs Link: https://qml.corefacilities.org/
13th March 2013
We are happy to announce that our slide scanner is now capable of scanning Fluroscence Stained slides. For more details please contact the lab.
19th Feburary 2013
I would like to say well done to Miss Rebecca Carroll for participating in the National Pathology Week which was held onthe 29th November 2012. This event helps to promote and educate the public of all disciplines in pathology including histopathology in which we specialise in. The feed back was very positive, see
21st October 2012
Our Publications and Courses tabs have been updated.
13th September 2012
We are happy to annouce that all staff have undertaken the 'Good Laboratory Practice' (GCP) course which meets the requirements for laboratory staff to participate and carry out work for Clinical Trials.
8th September 2012
We have just received confirmation that the department has passed its latest CPA inspection and maintains its accreditation. The team has done a brilliant job and we only received 6 non critical non-conformities which were only minor document changes. Once again good job guys!
August 2012
In 2006 the Core Pathology department participated in the Whitaker International Program (http://www.whitaker.org/grants/overview). This involves joint research projects between students from the USA and host laboratories around the world. The project title was 'Arterial Elasticity: Histological and Histochemical Analysis' and was headed by Professor Steve Greenwald (Pathology Group) in collaboration with Texas A&M Univeristy. Dr. Luke Timmins (http://www.whitaker.org/fsdirectory/info/29) was the lucky student who spent a year in our department and was a major asset, not just academically but he also became a member of the team and formed close friendships with its members. He now has a post doc position at The University of Atlanta and we continue to have close ties, which has helped our department braoden our academic contacts and research interests. The department benefited considerably from this program, so as they have now updated their website, I thought I would share this information in case it is of interest to other groups.
Feburary 2012
The department was asked to participate in a documentary on BBC 1 called 'Death Unexplained'. This is due to the work we carry out for multiple Coroners around London. The documentary follows Coroners' cases from the start to end covering all aspects including the laboratory tests. Please check out the program and see what else we get up to.
