Friday 16 June, 2pm
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Speaker: Dr Adam Byron, University of Manchester
Title: "Adhesion protein control of nuclear membrane signalling and gene expression in cutaneous SCC cells"
Adam's research aims to understand how cellular interactions with, and mechanoresponses to, the tumour microenvironment elicit signals at the nucleus that control fundamental aspects of cancer cell behaviour, including regulation of gene expression. He uses systems-level approaches, integrating state-of-the-art proteomics, sequencing, bioinformatics, functional cell biology, super-resolution imaging and cancer models, to discover new properties of cancer cell adhesion networks.
Adam studied Biochemistry at the University of Warwick and spent a year of his degree working at AstraZeneca. He received his PhD in Biochemistry from the University of Manchester, where he studied cell adhesion in the laboratory of Professor Martin Humphries, and where he stayed to undertake postdoctoral work. Here, he developed methodologies for the isolation and proteomic analysis of integrin adhesion complexes, which led to the description of the first experimentally defined integrin proteomes and insight into the complexity of the molecular machinery of cell adhesion. He then moved to the research group of Professor Margaret Frame at the University of Edinburgh, where he used integrative 'omic approaches to investigate the dysregulation of cell adhesion proteins in cancer. He later took up a Research Fellow position in the Institute of Genetics and Cancer, University of Edinburgh, where his interdisciplinary research revealed new roles for adhesion proteins in the nucleus of cancer cells. In 2022, he was recruited to an independent lectureship and group leader position at the University of Manchester.