Dr Paul Ryan , BDS, MFDS (RCS Eng.), MClinDent (Perio.), MPerio (RCS Ed.), FDS (Rest. Dent.) (RCS Ed.), PGCert FHEA, PhDClinical Senior Lecturer in Restorative Dentistry and Periodontology Co-Director of Undergraduate Dental Education Email: p.l.ryan@qmul.ac.ukTelephone: +44 (0) 20 7882 6341Room Number: Office 4, Floor 4, Institute of DentistryProfileTeachingResearchPublicationsProfile Dr Paul Ryan is a Clinical Senior Lecturer and Honorary Consultant in Restorative Dentistry with a Special interest in Periodontology. He is a GDC registered Specialist in Periodontics, Endodontics, Prosthodontics and Restorative Dentistry based at the Institute of Dentistry, Queen Mary University of London. The theme of his research is understanding the heterogeneity of immune responses in health and in oral diseases including periodontal disease. Paul obtained his primary dental degree (BDS) from the GKT Dental Institute (Kings College London) in 2003 with distinction. He went on to work in general dental practice and as a Senior House Officer in Oral Surgery and Restorative Dentistry at the Bristol Dental Hospital and subsequently at The Royal London Hospital. He was appointed as an Academic Specialist Registrar in 2007 and was awarded his Clinical Masters (MClinDent) in Periodontics with distinction in 2010, Membership in Periodontics in 2011, PhD in 2014 and FDS (Restorative Dentistry in 2019). Paul was awarded a prestigious Royal College of Surgeons/Wellcome Trust Research Training Fellowship in 2011 to investigate the pathogenesis of Bisphosphonate-related Osteonecrosis of the Jaw and completed his PhD in Clinical Immunology in December 2014. He was subsequently awarded a Starter Grant for Clinical Lecturers from the Academy of Medical Sciences which funds his current research investigating the biology of unconventional T cells (Gamma delta T cells). The theme of his research is understanding the heterogeneity of T cell immune responses in health and in oral diseases including periodontal disease. He teaches on both the undergraduate BDS and the DClinDent programmes in Periodontology and Prosthodontics and is a Fellow of the Higher Education Academy (FHEA). In addition, he is also involved in the delivery of postgraduate courses in Periodontology and Implantology for both the London Deanery and the International Team for Implantology (ITI) Centre: Centre for Oral Immunobiology and Regenerative Medicine TeachingDr Ryan lectures on both the undergraduate BDS and the DClinDent programmes in Periodontology and Prosthodontics. He is also involved in supervision of research projects for the DclinDent programme. In addition, he is also involved in the delivery of postgraduate courses in Periodontology and Implantology for the London Deanery and is also a Speaker for the International Team for Implantology (ITI). He has completed a Postgraduate Certificate in Academic Practice at QMUL and is a Fellow of the Higher Education Academy (FHEA). He is currently external examiner at Trinity College Dublin for the BDS Year 2 examination.ResearchResearch Interests: The theme of Dr Ryan’s research is understanding the heterogeneity of immune responses in health and in oral diseases including periodontal disease. Paul was awarded a prestigious Royal College of Surgeons/Wellcome Trust Research Training Fellowship in 2011 to investigate the pathogenesis of Bisphosphonate-related Osteonecrosis of the Jaw and completed his PhD in Clinical Immunology in December 2014. He was subsequently awarded a Starter Grant for Clinical Lecturers from the Academy of Medical Sciences which funds his current research investigating the biology of unconventional T cells (Gamma delta T cells). Paul is also involved in the Barts Centre for Squamous Cancer which is a cross-institute collaborative centre at QMUL, bringing together research groups with diverse expertise from across the School of Medicine and Dentistry to tackle the problem of squamous cancer and drive clinical innovation. PublicationsManuscripts Paul L Ryan, Md. Samiul Hasan, Lesley A Bergmeier, Farida Fortune Circulating NK cells and their subsets in Behçet’s Disease Clin Exp Immunol. 2017 May;188(2):311-322. doi: 10.1111/cei.12939. Epub 2017 Mar 13. Paul L. Ryan, Nital Sumaria, Christopher J. Holland, Claire M. Bradford, Natalia Izotova, Capucine L. Grandjean, Ali S. Jawad, Lesley A. Bergmeier, and Daniel J. Pennington. Biological Sciences - Immunology and Inflammation: Heterogeneous yet stable Vd2(+) T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals. Proceedings of the National Academy of Sciences (PNAS) 2016; 113:14378-14383 Ryan P. Osteonecrosis snapshot. Br Dent J. 2013 Apr; 214(8):373-4. Kingsmill VJ, McKay IJ, Ryan P, Ogden MR, Rawlinson SC. Gene expression profiles of mandible reveal features of both calvarial and ulnar bones in the adult rat.Journal of Dentistry 2013 Mar;41(3):258-64. Ryan PL, Piper KM, Hughes FJ. Langerhans cell histiocytosis: a diagnostic dilemma. Dent Update. 2012 Dec;39(10):716-8, 720 Rawlinson SC, McKay IJ, Ghuman M, Wellmann C, Ryan P, Prajaneh S, Zaman G, Hughes FJ, Kingsmill VJ. Adult rat bones maintain distinct regionaliased expression of markers associated with their development. PLoS One 2009 Dec;4(12);e85358 Theses PhD (December 2014) – Thesis (Queen Mary University of London) - The characterisation of human gd T cells in health and disease; Do Vg9Vd2 T cells play a role in the pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ)? MClinDent (Perio) (September 2009) – Thesis (Queen Mary University of London) Positional Identity Gene Expression in Osteoblasts Isolated from Distinct Anatomical Sites. Posters Ryan PL, Cheng L, Bergmeier LA, Pennington DJ – Pain and Quality of Life Outcomes in Medication related Osteonecrosis of the Jaw: A Case Series. International Association of Dental Research (IADR) July 2018 Ryan P, Bergmeier LA, Pennington DJP et al. Variation in gd T cells across a Healthy Adult Population. Penn Perio Conference 2017, University of Pennsylvania USA Ryan P, Bergmeier LA, Pennington DJP – Phenotypic comparison between Vd1 and Vd2 human gd T cells William Harvey Day 2017 (QMUL) and Academy of Medical Sciences Winter Science Meeting Ryan P, Bergmeier LA, Pennington DJP A phenotypic and functional re-evaluation of human Vd2(+) T cells across healthy individuals European Congress of Immunology Vienna 2015 Ryan P, Bergmeier LA, Pennington DJP Phenotypic characterisation of Human Vg9Vd2 T-cells ICI Milan August 2013 Ryan P, Bergmeier L and McKay IJ - Bisphosphonate related osteonecrosis of the Jaw – An immunological based phenomenon?NIHR Wellcome Dental Academic Meeting May 2012Gamma delta T-cell Conference Freiburg, Germany June 2012William Harvey Day QMUL 2012 Ryan P, Chatzopoulou D, Gillam D, Besas P and Turner W – Surgical excision of an epulis, case report – Best Clinical Poster at 2011 BSP Spring Meeting Ryan P, Rawlinson SCF, Ghuman M, McKay IJ, Hughes FJ Positional Identity Gene Expression in Osteoblasts Isolated from Distinct Anatomical Sites –June 2009 Bone Research Society & British Society for Matrix Biology. Oral Ryan P, Bergmeier LA, Pennington DJP A phenotypic and functional re-evaluation of human Vd2(+) T cells across healthy individuals BSODR Cardiff September 2015 Senior Colgate Research Prize, Highly Commended. Ryan P, Bergmeier LA, Pennington DJP The Characterisation of human gd T cells in health and disease – Oral Presentation – William Harvey Day 2014 – QMUL Research Day Ryan P, Rawlinson SCF, Ghuman M, McKay IJ, Hughes FJ Positional Identity Gene Expression in Osteoblasts Isolated from Distinct Anatomical Sites –Oral Presentation of British Society of Dental Research (Mineralised Tissue Group) September 2009.