Professor Nikolaos Donos, DDS, MS, FHEA, FDSRCSEng, PhD Professor & Chair Periodontology and Implant Dentistry, Director of Research, Director Centre for Oral Clinical Research Email: n.donos@qmul.ac.ukTelephone: +44 (0) 20 7882 6318Room Number: Office 3, Floor 5, Institute of DentistryWebsite: http://www.dentistry.qmul.ac.ukProfileResearchPublicationsProfile Professor Nikos Donos is the Director of Research, Professor & Chair of Periodontology and Implant Dentistry, Director of Clinical Research, Director of the Centre for Oral Clinical Research at the Institute of Dentistry, Faculty of Medicine and Dentistry, Queen Mary University of London (QMUL). Prof. Donos is also the Director of the ITI scholarship Centre and the Director of the Osteology Research Scholarship Centre, both at QMUL. In 2009, Professor Donos has been awarded the title of Honorary Professor at the Faculty of Dentistry in Hong Kong, in 2012 the title of Adjunct Professor at the Dental School, Griffith University in Australia, in 2015 the title of Honorary Professor at UCL-Eastman Dental Institute and in 2019 the title of Honorary Professor, School of Dentistry, University of Queensland, Australia. In 2024, Prof. Donos was awarded two prestigious awards: the IADR Distinguished Scientist in Periodontal Disease Award and the EFP Distinguished Scientist Award. Furthermore, in 2011, Professor Donos was awarded the IADR- Periodontology Group award in Periodontal Regenerative Medicine and in 2019 the American Academy of Periodontology (AAP) Clinical Research Award for his contribution as co-author for “outstanding published scientific manuscript with direct clinical relevance and application to the practice of periodontics”. In 2004, Professor Donos received the European Association of Osseointegration (EAO)- Basic Science Research Award. Professor Donos is a Past President of the British Society of Periodontology & Implant Dentistry (BSP) (2020), the Chair of the European Federation of Periodontology (EFP) Education Committee (2023-2026) and is the Lead for Science Committee and a board member of the Osteology Foundation- Switzerland, as well as the Academic Representative at the Committee of the Association of Dental Implantology (ADI)(UK). Prof. Donos is the Associate Editor for Periodontology 2000, a topic editor (2022) for Frontiers in Bioengineering and Biotechnology and is/has been involved as editorial board member in international peer-reviewed journals in the field of Periodontology and Implant Dentistry. Prof. Donos has published more than 260 peer reviewed publications (Donos N - Search Results - PubMed (nih.gov)), is the editor of 5 textbooks and author/co-author of 15 book chapters in the field of Periodontology and Implant Dentistry. Furthermore, during his career, Professor Donos is very successful in being awarded research grants from different funding bodies and the industry. Prof. Donos is/has been involved as reviewer/participant in most of consensus conferences for the European Federation of Periodontology (EFP), the European Association of Osseointegration (EAO), The International Team for Oral Implantology (ITI) and the Osteology Foundation which provide the most up-to-date evidence- based information for different clinical situations in the field of Periodontology and Implant Dentistry. Prof Donos has significant clinical experience in providing advanced treatment modalities to patients suffering from severe periodontal disease. Those modalities include all steps (non-surgical and surgical) for the treatment of periodontal disease including periodontal and bone tissue regeneration and replacement of missing teeth with dental implants. Furthermore, Professor Donos has significant experience in non-surgical and surgical treatment of peri-implant diseases (peri-implant mucositis and peri-implantitis). All the above clinical problems and their treatments are topics that Professor Donos regularly covers in his lectures on a national and international level. Centre: Centre for Oral Immunobiology and Regenerative Medicine Centre: Centre for Oral Clinical Research ResearchResearch Interests:Research Profile Professor Nikos Donos research profile include a wide range of activities including systematic reviews leading to treatment guidelines, translational research, experimental medicine studies as well as randomized controlled clinical trials in the area of Wound Healing, Soft & Hard Tissue Regeneration Implant Dentistry and Periodontal Medicine. These areas of research are part of the established research themes in COIRM and COCR Together with his team, Professor Donos has developed preclinical and clinical research expertise in the above mentioned areas, which attract funding from Charities, research funding bodies and industry. Currently, Professor Donos is involved in a number of wound healing studies following different treatment modalities in healthy and systemically compromised patients COIRM/COCR. Furthermore, together with his team, he is developing experimental medicine studies where biologic samples are used through a number of platform technologies to develop novel diagnostic and prognostic information in relation to periodontal and peri-implant diseases COIRM/COCRPublicationsFurther details can be found at: https://www.ncbi.nlm.nih.gov/pubmed/?term=Donos+N All QM publications Randomized Clinical trials Donos N, Horvath A, Calciolari E, Mardas N Immediate provisionalization of bone level implants with a hydrophilic surface. A five-year follow-up of a randomized controlled clinical trial Clin Oral Implants Res. 2019 Feb; 30 (2): 139-149. Donos N, Horvath A, Mezzomo LA, Dedi D, Calciolari E, Mardas N. The role of immediate provisional restorations on implants with a hydrophilic surface: A randomised, single-blind controlled clinical trial. Clin Oral Implants Res. 2018 Jan; 29 (1): 55-66. D'Aiuto F, Gkranias N, Bhowruth D, Khan T, Orlandi M, Suvan J, Masi S, Tsakos G, Hurel S, Hingorani AD, Donos N, Deanfield JE; TASTE Group Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator – masked, randomised trail Lancet Diabetes Endocrinol. 2018 Dec; 6 (12): 954-965. Rakmanee T, Griffiths GS, Auplish G, Darbar U, Petrie A, Olsen I, Donos N. Treatment of intrabony defects with guided tissue regeneration in aggressive periodontitis: clinical outcomes at 6 and 12 months. Clin Oral Investig. 2016 Jul; 20(6): 1217-122 Experimental studies: Tatarakis N, GkraniasN, Darbar U, Donos N Blood flow changes using a 3D xenogeneic collagen matrix or a subepithelial connective tissue graft for root coverage procedures: a pilot study. Clin Oral Invest 2018 May;22(4):1697-1705 Nizam N, Eren G, Akcalı A, Donos N. Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: A split-mouth histological and histomorphometric study. Clin Oral Implants Res. 2018 Jan;29(1):67-75 Sousa V, Nibali L, Spratt D, Dopico J, Mardas N, Petrie A, Donos N. Peri-implant and periodontal microbiome diversity in aggressive periodontitis patients: a pilot study Clin Oral Implants Res 2017 May; 28(5): 558-570. Aguayo S, Donos N, Spratt D, Bozec L. Nanoadhesion of Staphylococcus aureus onto Titanium Implant Surfaces. J Dent Res. 2015 Aug; 94(8): 1078-1084. Retzepi M, Calciolari E, Wall I, Lewis MP, Donos N. The effect of experimental diabetes and glycaemic control on guided bone regeneration: histology and gene expression analyses. Clin Oral Implants Res.2018 Feb;29(2):139-154 Calciolari E, Hamlet S, Ivanovski S, Donos N Pro-osteogenic properties of hydrophilic and hydrophobic titanium surfaces: Crosstalk between signalling pathways in in vivo models J Periodont Res. 2018 Aug;53(4):598-609 Nibali L, Sousa V, Davrandi M, Spratt D, Alyahya Q, Dopico J, Donos N. Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis. J Clin Periodontol. 2020 Aug;47(8):980-990. Systematic Reviews: Donos N, Calciolari E, Brusselaers N, Goldoni M, Bostanci N, Belibasakis GN. The Adjunctive use of host modulators in non-surgical periodontal therapy. A systematic review of randomized, placebo controlled clinical studies J Clin Periodontol 2020 Jul:47 Supp 22:199 - 238 Koidou VP, Chatzopoulos GS, Tomas I, Nibali L, Donos N. Expression of gingival crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review Clinical Oral Investig 2020 Jan;24(1):487-502. Arias-Bujanda N, Regueira-Iglesias A, Balsa-Castro C, Nibali L, Donos N, Tomás I Accuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: A systematic review and meta-analysis J Clin Periodontol 2019 Dec;46(12):1166-1182 Arias-Bujanda N, Regueira-Iglesias A, Balsa-Castro C, Nibali L, Donos N, Tomás I. Accuracy of single moecluar biomarkers in saliva for the diagnosis of periodontitis: a systematic review and meta analysis J Clin Periodontal 2020 Jan;47(1):2-18 Halai H, Somani C, Donos N, Nibali L Periodontal status of children with primary immunodeficiencies:a systematic review Clin Oral Investig 2019 Oct 2018 doi 10:1007/s00784-019-03055-z [Epub ahead of print] Nibali L, Koidou VP, Hamborg T, Donos N. Empirical or microbiologically guided Systemic antimicrobials as adjuncts to non-surgical periodontal therapy? A systematic review. J Clin Periodontol. 2019 Oct;46(10):999-1012 Liu LS, Gkranias N, Farias B, Spratt D, Donos N. Differences in the subginigval microbial population of chronic periodontitis in subjects with and without type 2 diabetes mellitus-a systematic review. Clin Oral Invest 2018 Nov;22(8):2743-2762 Akcali A, Trullenque-Eriksson A, Sun C, Petrie A, Nibali L, Donos N. What is the effect of soft tissue thickness on crestal bone loss around dental implants? A systematic review. Clin Oral Implants Res. 2017 Sep; 28(9): 1046-1053. Mardas N, Trullenque-Eriksson A, MacBeth N, Petrie A, Donos N. Does ridge preservation following tooth extraction improve implant treatment outcomes: a systematic review: Group 4: Therapeutic concepts & methods. Clin Oral Implants Res. 2015 Sept;26 Suppl 11:180-201. Invited reviews: Donos N, Dereka X, Calciolari E. The use of bioactive factors to enhance bone regeneration. A narrative review J Clin Periodontol. 2019 Jun;46 Suppl 21:124-16 Calciolari E, Donos N Proteomic and transcriptomic approaches for studying Bone Regeneration in Health and Systemically compromised conditions. Proteomics Clin Appl 2020 May;14(3):e1900084 Donos N, Park JC, Vajgel A, de Carvalho Farias B, Dereka X Description of the periodontal pocket in preclinical models: limitation and considerations. Periodontol 2000 2018 Feb;76(1):16-34 Graziani F, Karapetsa D, Mardas N, Leow N, Donos N. Surgical treatment of the residual periodontal pocket. Periodontol 2000. 2018 Feb;76 (1):150-163. Calciolari E, Donos N The use of omics profiling to improve outcomes of bone regeneration and osseointegration. How far are we from personalized medicine in dentistry? J. Proteomics. 2018 Sep 30;188:85-96