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Institute of Health Sciences Education - Faculty of Medicine and Dentistry
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Professor Bruce Kidd

Bruce

Head of Year 4

Email: b.l.kidd@qmul.ac.uk

Profile

I have over thirty years of experience of planning and delivering medical education programs at both undergraduate and postgraduate levels and during this time have seen important developments in medical education including the shift to student centered approaches to teaching and learning. .

Teaching

I am currently Head of MBBS Year 4, Deputy Dean for Education within Barts & The London School of Medicine and past Chair of the Medical Curriculum Committee with the remit to critically appraise and revise the MBBS program. I have led a team that has introduced a number of program enhancements related to curricular design, delivery, student assessment and student support.

I have served as Chair of a number of national postgraduate training committees which oversaw the introduction of a number of quality measures including more rigorous feedback mechanisms from trainees, changes to syllabus, as well as more general curriculum development. 

 

Research

Research Interests:

My research activities developed in order to explore interactions between the nervous and locomotor systems. The central aims were: (1) to characterise pharmacological mechanisms of joint pain that have potential for therapeutic intervention; and (2) understand the influence of neurogenic mechanisms on the outcome of inflammatory arthritis.  In collaboration with academic and industrial groups I developed several novel experimental models of arthritic pain. My group also developed novel (capsaicin-based) clinical techniques to assess changes within pain pathways during inflammation that have been adopted by a number of pain research groups . We published the first direct clinical evidence of enhanced sensitivity within central neurones during chronic arthritis. My group also used a variety of experimental models to characterise the distribution of sensory fibres and neurally-derived peptides within the mammalian joint. The influence of these peptides (eg substance P) on aspects of the inflammatory cascade was been explored.

Publications

ARTICLES PUBLISHED IN SCIENTIFIC JOURNALS (peer reviewed except those

marked with *)

  1. B Kidd and M Robertson. Toxic Shock Syndrome and Vaginal Tampons. New Zealand Medical Journal, 1981;93:149-150.
  2. L McGuigan, H Hart, B Kidd, R Grigor and T Moore. Work capacity in Ankylosing Spondylitis.Annals of Rheumatic Disease, 1984;43:604-607
  3. B Kidd, H Hart and R Grigor. Clinical Features of Meningococcal Arthritis. Annals of Rheumatic Disease, 1985;44:790-792.
  4. L McGuigan, H Hart, P Gow, B Kidd, R Grigor and T Moore. The functional significance of sacroiliitis and ankylosing spondylitis in Reiter's Syndrome. Clinical and Experimental Rheumatology 1985;3/4:311-315.
  5. M Scott, B Kidd, M Croxson and M Evans. Admission Thyroid Testing in Elderly Patients. Australian and New Zealand Journal of Medicine, 1986;16:699-702.
  6. B Kidd and M Cawley.Diagnostic Delay in Spondarthritis. British Journal of Rheumatology, 1988;17:230-2.
  7. B Kidd, M Mullee, A Frank, M Cawley. Disease expression of ankylosing spondylitis in males and females. Journal of Rheumatology, 1988;15:1407-1409.
  8. P Merry, B Kidd, P Mapp, C Stevens, D Blake. Mechanisms of Persistent Synovitis.

Scand J Rheum 1988;76:85-93.

  1. B Kidd, M Walters, K Moore, J Smith and M Cawley. Immunohistochemical features

of ankylosing spondylitis. A comparison with rheumatoid arthritis. Annals of

Rheumatic Disease 1989;48:92-98.

  1. Hargraves C, Cooper C, Kidd B, Ellis E. Frozen shoulder and cervical spine disease.

British Journal of Rheumatology. 1989;28:78-9.

  1. Blake D, Merry P, Kidd B, Gray L, Lunec J.The inflamed human joint is an example of hypoxic-reperfusion injury.Lancet 1989;1:289-293.
  2. Mani R, Cooper C, Kidd BL, Cole JD, Cawley MID.Use of laser doppler flowmetry and transcutaneous oxygen tension electrodes to assess local autonomic dysfunction in patients with frozen shoulder. J Royal Soc Med 1989;82:536-538.
  3. Kidd BL, Mapp PI, Gibson SJ, Polak JM, O'Higgins F, Buckland-Wright JC, Blake DR. A neurogenic mechanism for symmetrical arthritis. Lancet 1989;2:1128-1130.
  4. Merry P, Kidd B, Blake D. How safe is it to give parenteral iron to a patient with

rheumatoid arthritis and iron deficiency anaemia? Br J of heumatology. 1989;28:22. 

  1. Merry P, Kidd B, Blake DR. Modification of rheumatic symptoms by diet and

            drugs.  Proc Nutrition Soc 1989;48:363-369.

  1. B Kidd, P Merry, P Mapp, D Blake. A neurogenic mechanism to explain symmetrical

synovitis. British Inflammation Research Association Letters 1989;2:10-13.

  1. McLean IL, Archer JR, Cawley MID, Pegley F, Kidd BL, Thompson PW.

Specific antibody response to the Mycobacterial 65 kDa stress protein in ankylosing

spondylitis and rheumatoid arthritis.Brit J Rheum 1990;24:426-429.

  1. Kidd BL, Polak JM, Blake DR.A neurogenic mechanism for symmetrical arthritis.

Lancet 1990;1:795.

  1. Kidd BL. The classification of HLA B27 positive inflammatory rheumatic disease.

DM Thesis, University of Southampton 1990.

  1. Mapp PI, Kidd BL, Gibson SJ, Terry JM, Revell PA, Ibrahim NBN, Blake DR, Polak
  2. Substance P-, calcitonin-related peptide- and C-flanking peptide of

neuropeptide Y-immunoreactive fibres are present in normal synovium but depleted

in patients with

rheumatoid arthritis. Neuroscience 1990;37:143-153.

  1. Kidd BL, Mapp PI, Blake DR, Gibson SJ, Polak JM. Neurogenic Influences in

arthritis Ann Rheum Dis 1990;49(8):649-652

  1. McLean IL, Kidd BL, Thompson PW, Cawley MID. Ankylosing spondylitis and

selective IgA Deficency. Ann Rheum Dis 1991;50:271.

  1. Kidd BL, Gibson SJ, Mapp PI, Zhao Y, Polak JM, Blake DR. Neuropeptides as

mediators of inflammation and chronic pain.Eur J Rheumatol and Inflamm

1991;11:46-65.

  1. Cruwys SC, Kidd BL, Mapp PI, Walsh DA, Blake DR. An alternative role for pain in

rheumatic disease. J Pain Soc 1991;9(2):37-40.(*)

  1. Mclean IL, Archer JR, Cawley MID, Kidd BL, Thompson PW. Immune complexes in

ankylosing spondylitis Ann Rheum Dis 1992;51:83-86.

  1. Berry H, Bird H, Black C, Blake D, Freeman A, Jayson M, Kidd B, Williams B,

Woolf A.A double-blind, multicentre, placebo controlled trial of lornoxicam in

patients with osteoarthritis of the hip and knee.Ann Rheum Dis 1992;51:238-242.

  1. Walsh DA, Mapp PI, Wharton J, Rutherford RD, Kidd BL, Revell PA, Blake DR,

Polak JM.The localisation and characterisation of Substance P receptors in human

rheumatoid synovial membrane. Ann Rheum Dis 1992;51:313-317.

  1. Cruwys SC, Kidd BL, Mapp PI, Walsh DA, Blake DR.The effects of calcitonin gene-

related peptide on formation of intra-articular oedema by inflammatory mediators.

Br J Pharmacol 1992;107;116-119.

  1. Mapp PI, Walsh DA, Cruwys SC, Kidd BL, Polak JM, Blake DR. Localisation of

neutral endopeptidase to the human synovium.J Rheumatol 1992:19;1838-1844.

  1. Garret N, Mapp PI, Kidd BL, Cruwys S, Blake DR. The role of substance P in

inflammatory arthritis. Ann Rheum Dis 1992;51:1014-1018.

  1. Kidd BL, Cruwys S, Mapp PI, Blake DR. The role of the sympathetic nervous system

in chronic joint pain and inflammation Ann Rheum Dis 1992:51;1188-1191.

  1. Garret NE, Cruwys SC, Jolliffe VA, Diemal LT, Blake DR Tomlinson DR, Kidd BL.

Substance P involvement in chronic arthritis. Neuropeptides 1993:24(4): 202.

  1. Davis AJ, Hawkes GE, Kidd BL, Mapp PI, Grootveld M. Generation of substance P

carbamate in neutral aqueous solution FEBS Letters 1993:329;249-252.

  1. Mapp PI, Terengi G, Walsh DA, Chen ST, Cruwys SC, Garrett N, Kidd BL, Polak

JM, Blake DR.Monoarthritis in the rat knee induces bilateral and time-dependent

changes in substance P and calcitonin gene-related peptide immunoreactivity in the

spinal cord. Neuroscience 1993; 57 (4) 1091-1096.

  1. Kidd BL, Blake DR.The role of the sympathetic nervous system in chronic joint pain

and inflammation  Ann Rheum Dis 1993: 52: 420.

  1. Kidd BL. The expanding role of the nervous system in arthritis. EULAR Bulletin

1993;4, 134-137 (*)

  1. Mapp PI, Walsh DA, Garrett NE, Kidd BL, Cruwys SC, Polak JM, Blake DR.

Effect of three animal models of inflammation on nerve fibres in the synovium.

Ann Rheum Dis 1994; 53: 240 - 246.

  1. Cruwys SC, Garrett NE, Perkins MN, Blake DR and Kidd BL. The role of bradykinin

B1 receptors in the maintenance of intra-articular plasma extravasation in chronic

antigen-induced arthritis. Br J Pharmacol 1994; 113: 940 - 944.

  1. Mapp PI, Kidd BL. Substance P in rheumatic disease Seminars of Arthritis and

Rheumatism 1994; 6 (S3); 3 - 9.

  1. Kidd BL, Wilson PJ, Evans PR and Cawley MD. Familial aggregation of

undifferentiated spondylarthropathy associated with HLA B7.Ann Rheum Dis 1995;

54: 125 - 128.

  1. Jolliffe VA, Anand P and Kidd BL.Assessment of cutaneous sensory and autonomic

axon reflexes in rheumatoid arthritis Ann Rheum Dis 1995; 54: 251 - 255.

  1. Garrett NE, Kidd BL, Cruwys SC and Tomlinson DR. Effect of streptozocin-induced

diabetes on substance P in experimental arthritis in the rat knee. Neurosci Lett

1995;

187: 201 - 204.

  1. Garrett NE, Kidd BL, Cruwys SC and Tomlinson DR. Changes in preprotachykinin

mRNA expression and substance P levels in dorsal root ganglia of monoarthritic rats:

Comparison with changes in synovial substance P levels.Brain Res 1995; 675: 203 –

  1.  
  2. Cruwys SC, Garrett NE and Kidd BL.Sensory denervation with capsaicin attenuates

inflammation and nociception in arthritic rats.Neurosci Lett 1995;193:205 - 207.

  1. Kidd BL, Cruwys SC, Garrett NE, Mapp PI, Jolliffe VA and Blake DR.

Neurogenic influences on contralateral responses during experimental rat

Monarthritis Brain Res. 1995; 688: 72 - 76.

  1. Kidd BL, Frenzel W.A multicenter, randomised double-blind study comparing

Lornoxicam with diclofenac in osteoarthritis J Rheumatol 1996: 105: 120 - 127.

  1. Garrett NE, Kidd BL, Cruwys SC and Tomlinson DR. Effect of streptozotocin-

diabetes on knee joint inflamation-induced changes in substance P and nerve

growth factor in the rat. Mol Brain Res. 1996; 42: 272 - 278.

  1. Kidd BL, Morris VH.The pathophysiology of joint pain.Ann Rheum Dis. 1996: 55: 5:

276-283

  1. Kidd BL and Morris VH. The role of the sympathetic nervous system in arthritis.

State of the Art Reviews. Physical Medicine and Rehabilitation. 1996: 10:1: 177 - 184

  1. Kidd BL. Problems with pain: Is the messenger to blame (Editorial) Ann Rheum Dis

1996: 55: 5: 275 (*)

  1. Morris VH, Cruwys SC & Kidd BL. Characterisation of capsaicin-induced

mechanical hyperalgesia as a marker for altered nociceptive processing in patients

with rheumatoid arthritis. Pain 1997; 71: 179 - 186.

  1. Garrett NE, Kidd BL, Cruwys SC and Tomlinson DR Effect of capsaicin on

substance P and nerve growth factor in adjuvant arthritis.Neurosci Lett 1997;230:5– 8.

  1. Edmonds SE, Winyard PG, Guo R, Kidd BL, Merry P, Langrish-Smith A, Hansen C,

Ramm S & Blake DR Putative analgesic activity of repeated oral doses of vitamin E

in the treatment of rheumatoid  arthritis. Results of a prospective placebo controlled

double blind trial.Ann Rheum Dis 1997; 56; 11: 649-655.

  1. Kelleher D, Rennell B, Kidd BL The effect of social context on pain measurement

J Musculoskeletal Pain 1998; 6 (2) : 77 - 87.

  1. Morris V, Cruwys SC, Kidd BL Increased capsaicin-induced hyperalgesia as a marker

of abnormal sensory activity in patients with fibromyalgia Neurosci lett 1998; 250 (3)

205 - 207.

  1. Woolf CJ, Bennet GJ, Doherty M, Dubner R, Kidd B, Koltzenburg M, Lipton R,

Loeser JD, Payne R, Torebjork E.Towards a mechanism based classification of pain.

            Pain 1999; 77: 227 – 229.

  1. Ellis L, Gilston V, Soo CC, Morris CJ, Kidd BL, Winyard PG.Activation of

transcription factor NFkB in the rat air pouch model of inflammation.Annals of the

Rheumatic Diseases 2000; 59:4: 303-30768.

  1. McCormack K, Kidd BL, Morris V.Assay of topically administered ibuprofen using a

model of post-injury hypersensitivity. A randomised double-blind placebo-controlled

study. European Journal of Pharmacology 2000; 56: 459 – 462

  1. Campbell EA, Gentry C, Patel S, Kidd B, Cruwys S, Fox AJ, Urban L. Oral anti-

hyperalgesic and anti-inflammatory activity of NK1 receptor antagonists in models

of inflammatory hyperalgesia of the guinea-pig.  Pain 2000; 87: 253 – 263.

  1. Hood VC, Cruwys SC, Kidd BL. Differential role of neurokinin receptors in human

lymphocyte and monocyte chemotaxis Regulatory Peptides. 2000; 96: 17 – 21.

  1. Kidd BL Urban L. Mechanisms of Inflammatory Pain. Br J Anaesth 2001;  87(1): 3 –

11

  1. Hood VC, Cruwys SC, Urban L, Kidd BL. The neurogenic contribution to synovial

infiltration and other outcome measures in a guinea  pig model of arthritis.

Neuroscience Letters. 2001; 299: 201 - 204

  1. Medhurst SJ, Walker K, Bowes M, Kidd BL, Glatt M, Muller M, Hattenberger M,

Vaxelaire J, O’Reilly T, Wotherspoon G, Winter J, Green J, Urban L. 

A rat model of bone cancer pain. Pain 2002 ; 96(1-2):129-40

  1. Jawad ASM, Kidd BL. Osteoporosis and pain. Osteoporosis Review. 2002; 10: 1 5
  2. Walker K, Medhurst SJ, Kidd BL, Glatt M, Bowes M, Patel S, McNair K,Kesingland

A, Green J, Chan O, Fox AJ, Urban LA. Disease modifying and anti-nociceptive effects

of the bisphosphonate, zoledronic acid in a model of bone cancer pain.

Pain 2002 Dec;100(3):219-29.           

  1. White PD, Henderson M, Pearson RM, Coldrick AR, White AG & Kidd BL.

Illness behaviour and psychosocial factors in diffuse upper limb pain disorder: A case-

control study.  J Rheumatol 2003 Jan;30(1):139-45

  1. Jawad AS Kidd BL. The GALS examination (letter). Rheumatology. 2003: 42(11):

1421-2

  1. Seegers HC, Hood VC, Kidd BL, Cruwys SC, Walsh DA. Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J. Pharmacol. Exp. Therapeut. 2003, 306, 8-12.
  2. Kidd BL, Inglis JJ, Vetsika E, Hood VC, De Felipe C, Bester H,  Hunt SP,

Cruwys SC.  Inhibition of inflammation and hyperalgesia in NK-1 receptor knock-out

mice. NeuroReport 2003 Dec 2;14(17):2189-92.

  1. Soo J, Arif S, Kidd BL, Jawad AS. Pyrexia, pelvic pain and thrombocytopenia in an

Asian man with Paget's disease of bone. Rheumatology. 2004 Jan;43(1):110-1 

  1. Fernihough J, Gentry C, Malcangio M, Fox A, Rediske J, Pellas T, Kidd B, Bevan S,

Winter J. Pain related behaviour in two models of osteoarthritis in the rat knee.

Pain. 2004 Nov;112(1-2):83-93

  1. Henderson M, Kidd BL, Pearson RM, White PD. Chronic upper limb pain: an

exploration of the biopsychosocial model. J Rheumatol. 2005 Jan;32(1):118-22.

  1. Inglis JJ, Nissim A, Lees DM, Hunt SP, Chernajovsky Y, Kidd BL.

The differential contribution of tumour necrosis factor to thermal and mechanical

hyperalgesia during chronic inflammation. Arthritis Research & Therapy 2005;7:807-

816  

  1. O’Shaughnessy MC, Vetsika E-K, Carleson J, Haigh R, Kidd BL, Winyard PG.

The effect of substance P on nitric oxide release in a rheumatoiud arthritis model. Inflamm Res 2006; 55: 236 - 240

75.       Kidd BL. Osteoarthritis and joint pain.   Pain. 2006 Jul;123(1-2):6-9. 76.       Kidd BL, Langford RM, Wodehouse T.  Arthritis and pain. Current approaches in the             treatment of arthritic pain. Arthritis Res Ther. 2007 Jun 11;9(3):214. 77.       Tucker AT, White PD, Kosek E, Pearson RM, Henderson M, Coldrick AR, Cooke             ED, Kidd BL. Comparison of vibration perception thresholds in individuals with             diffuse upper limb pain and carpal tunnel syndrome. Pain. 2007 Feb;127(3):263- 9. 78.       Averill S, Inglis JJ, King VR, Thompson SWN, Cafferty WBJ, Shortland PJ, Hunt SP, Kidd BL, Priestley JV. Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis. Neuroscience 2008; 9;155(4):1227-36.79.      Graven-Nielsen T, Wodehouse T, Langford RM, Arendt-Nielsen L, Kidd BL.Normalisation of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum. 2012 Mar 15. doi: 10.1002/art.34466. [Epub ahead of print]  

B          BOOK CHAPTERS       

  1. Merry P, Kidd BL, Blake DR. Synovitis of the joint is an example of reperfusion

injury. Studies of synovial microvascular perfusion using laser doppler flowmetry.

In: Free radicals, metal ions and biopolymers. Eds Beaumont P, Deeble D, Parsons B,

and C Rice-Evans. Richelieu Press, London UK 1989, pp 199-215.

  1. Allen RE, Kidd BL, Blake DR.A radical cause for synovitis - a discussion of oxygen

            radical and neurogenic influences on inflammation.In: Horizons in Medicine. Ed

            Bunch C.  Bailliere Tindall, London. 1989, pp 321-340

  1. McLean IL, Archer JR, Cawley MID, Pegley F, Kidd BL, Thompson PW.

Antibodies to the mycobacterial 65 kDa stress (heat shock) protein in ankylosing spondylitis and rheumatoid arthritis. In: Stress proteins in inflammation.  Burdon R, Rice-Evan C, Blake D, Winrow V, eds. The Richellieu Press: 1990: 183 - 194.

  1. Kidd BL, Cruwys SC, Mapp PI, Walsh DA, Blake DR. Neuropeptides in joint

inflammation. In: Rheumatology, State of the Art.  G Balint et al., Editors

Elsevier Scientific Publishers BV. 1992;132-134.

  1. Kidd BL. What are the mechanisms of musculoskeletal pain. Balliere's Clinical

Rheumatology 1999;13(2): 217 - 230

  1. Kidd BL, Mapp P, Blake D Pain mechanisms in chronic arthritis.Rheumatoid

arthritis. Eds: Firestein G, Panayi G, Wollheim F. Oxford University Press 2000 pp

201 – 210.      

  1. Kidd BL & Richardson PM. How does neuropathophysiology affect the signs and

symptoms of spinal disease? Best Pract Res Clin Rheumatol. 2002 Jan;16(1):31-42

  1. Kidd BL. Nociceptive mechanisms in the inflammatory arthropathies. In: Pain 2002 –

An updated review. Ed MA Giamberadino, IASP Press, Seattle, 2002

  1. Kidd BL & Jawad A Cronic Joint Pain. In: Textbook of Clinical Pain Management

            Eds: Rice, Warfield, Justins & Eccleston. Arnold Publishers 2002

  1. Kidd BL. Peripheral and central pain mechanisms in osteoarthritis.

In Osteoarthritis. Second Edition Eds: KD Brandt, M Doherty, LS Lohmander.

Oxford University Press. 2003 pp 185 - 189

12        Kidd BL. Chronic pain, pain concepts. In Textbook of Sports Medicine.

Ed M Hutson 2004

  1. Kidd BL, Photiou A, Inglis JJ. The role of inflammatory mediators on nociception

and pain in arthritis. 2004. Osteoarthritic joint pain. Wiley, Chichester (Novartis         Foundation Symposium) p 122 – 138.

  1. Kidd BL. Pain mechanisms in musculoskeletal disease. In: Pain 2005 – An updated

review. Ed DM Justins. IASP Press Seattle 2005.  

  1. Dieppe P, Conaghan P, Kidd B, Creamer P. Osteoarthritis and related disorders. In:

Waldman’s Pain Management .

16        Kidd BL. Pain mechanisms in rheumatoid arthritis. In Rheumatoid Arthritis. Eds F Wollheim. 2006

17        Kidd BL. The mechanisms of chronic pain. In: H Breivik and M Shipley (eds),

Pain: Best Practice and Research Compendium. Elsevier, Edinburgh, 2006, pp.17-24.

 

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