Stylianos Iliadis

Profile

Project Title: Structural bioinformatics and chemogenomics approaches to navigate GPCR-ligand interaction space

Content: Stylianos has a degree in Pharmacy (Aristotle University of Thessaloniki - Greece) and an MSc in Medicinal Chemistry (University of Copenhagen - Denmark). During his undergraduate studies, he worked on wet-lab projects, but after realising the impact of computational methods in Drug Design, he undertook a Computational Drug Design MSc project. In this project, he worked on the design and discovery of novel ligands for orphan GPCRs by applying related computational methods such as MD simulations and molecular docking.

Stylianos' research interests lie in the Computational Drug Design against GPCRs. GPCRs have a central role in cellular communication which makes them involved in numerous pathological situations. Due to their complexity, the application of computational methods is necessary to study them effectively and eventually target them for reverting pathology. The efficient design of ligands can take place via the integration of chemical, biological, and structural information, which allows for making better decisions during the drug design process.

Recent advancements in GPCRs structural biology have provided an unprecedented number of GPCR structures, thereby revealing details on GPCR structures, based on which structure-based drug design (SBDD) methods can be applied. Additionally, chemogenomics and structural bioinformatics methods as well as drug design-relevant data such as ligand molecular and structural properties can also be harnessed and integrated to effectively design novel ligands. During his AIDD project, Stylianos will work on the development and application of machine learning-augmented structural bioinformatics and chemogenomics methods for guiding SBDD efforts.

Funding: Biotechnology and Biological Sciences Research Council (BBSRC)

Research

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