Dr Aisah Aubdool

Profile

ORCID iD: 0000-0002-4712-9421

Aisah Aubdool is a Lecturer in Cardiovascular Pharmacology at the William Harvey Research Institute, Queen Mary University of London (QMUL). She obtained a BSc in Pharmacology at King’s College London in 2009 before completing an MRes in Integrative Biomedicine where she received extensive in vivo training in mammalian biology. She subsequently obtained her PhD in the field of cardiovascular medical research under the mentorship of Professor Susan D Brain at the same institution. During her PhD research, she identified transient receptor potential ankyrin 1 (TRPA1) as a vascular cold sensor and made significant contribution to the mechanistic understanding of TRPA1 in vascular homeostasis. In 2014, she started her post-doctoral research training, also with Professor Susan D Brain in collaboration with Novo Nordisk where she demonstrated that a novel α-Calcitonin Gene-Related Peptide (CGRP) analogue protects against the cardiac dysfunction associated with high blood pressure.

In 2016, Aisah joined Professor Adrian J Hobbs’ group at the William Harvey Research Institute, to investigate the role of C-type natriuretic peptide (CNP) in angiogenesis and vascular remodelling. During this time, she identified CNP as a previously unrecognised, yet vital, pro-angiogenic mediator that is critically involved in protecting against human vascular ischemia. The outstanding calibre of her research has been recognised by prestigious awards and prizes from the BBSRC (Sparking Impact Award 2015), British Pharmacological Society (BPS Bill Bowman Award-2017, Pickford Award-2019), American Heart Association (2017), North American Vascular Biology Organization (NAVBO-2019) & the Federation of European Pharmacological Societies (EPHAR-2022). In 2022, she was appointed as a Lecturer in Cardiovascular Pharmacology at QMUL.

Aisah is involved in various teaching activities within the BSc Pharmacology and Innovative Therapeutics, MBBS and MRes in Cardiac & Vascular Medicine programmes. She is a mentor for the WHRI BAME Mentoring Scheme and works closely with the WHRI society to support undergraduate students at QMUL. She is also the ECR lead for the Faculty of Medicine 2021-2026 Strategy – Integrated Physiology and 3D Models.

In addition to her research, Aisah is currently a BPS ambassador coordinator. She was also the Chair of the IUPHAR ECR Committee (2018-2022) where she advocates for early career pharmacologists worldwide. She is a member of the BPS Engagement Committee and Senior Editor for the BPS magazine Pharmacology Matters.

Research

Aortic aneurysm is a life-threatening disease that is caused by focal enlargement or 'ballooning' of the aorta (the body’s largest blood vessel) in the abdominal (AAA) or thoracic (TAA) regions. If left untreated, it ultimately leads to rupture and exsanguination, accounting for 1-2% of total cardiovascular mortality. Aortic aneurysm is often characterised by chronic inflammation, haemodynamic stress and structural weakness; it is particularly common in patients with connective tissue disorders such as Marfan syndrome. Aortic aneurysm is currently detected through screening and is then monitored by ultrasound until it reaches an "intervention threshold" in patients. Intervention approaches currently includes high-risk surgery such as endovascular repair or open surgery. As there are a no pharmacological treatments, development of novel drug-based therapies for aortic aneurysm is desperately needed.  

Her research focusses on understanding the pathophysiological mechanisms involved in forming and developing aortic aneurysm to develop novel therapeutic approaches. She is particularly interested in understanding the role of natriuretic peptides in both TAA and AAA.

Publications

• Lowe VJ, Aubdool AA, Moyes AJ et al. (2024). Cardiomyocyte-derived C-type natriuretic peptide diminishes myocardial ischaemic injury by promoting revascularisation and limiting fibrotic burden. nameOfConference

  
  

  DOI: 10.1016/j.phrs.2024.107447

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100298
• Thakore P, Clark JE, Aubdool AA et al. (publicationYear). Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy. nameOfConference

  
  

  DOI: 10.3390/biom14040442

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98795
• Aubdool AA, Moyes AJ, Perez-Ternero C et al. (2023). Abstract 15171: Endothelium-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Abdominal Aortic Aneurysm. nameOfConference

  
  

  DOI: 10.1161/circ.148.suppl_1.15171

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/93582
• Dignam JP, Perez-Ternero C, Aubdool AA et al. (2023). C-Type Natriuretic Peptide Signalling Attenuates the Development of Pulmonary Hypertension and Right Ventricular Remodelling. A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Moyes A, Sand C, Aubdool A et al. (2023). C-type Natriuretic Peptide Attenuates Endothelial and Cardiac Dysfunction During Endotoxemia and Polymicrobial Sepsis. B45. NEW STUDIES IN SEPSIS AND INFECTIOUS DISEASES

  
  

  DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3433

  
  

  QMRO: qmroHref
• Perez-Ternero C, Aubdool AA, Makwana R et al. (2022). C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis. nameOfConference

  
  

  DOI: 10.1073/pnas.2116470119

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/77738
• Grange RMH, Preedy MEJ, Renukanthan A et al. (2022). Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature. nameOfConference

  
  

  DOI: 10.1111/bph.15593

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73258
• Argunhan F, Thapa D, Aubdool AA et al. (2021). Calcitonin Gene-Related Peptide Protects Against Cardiovascular Dysfunction Independently of Nitric Oxide In Vivo. nameOfConference

  
  

  DOI: 10.1161/hypertensionaha.120.14851

  
  

  QMRO: qmroHref
• Argunhan F, Thapa D, Aubdool AA et al. (2020). αCGRP can act independently of NO to rescue blood flow in the mesenteric microvasculature in vivo. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• (2019). Correction. nameOfConference

  
  

  DOI: 10.1096/fj.201800395rrerr

  
  

  QMRO: qmroHref
• Perez-Ternero C, Aubdool AA, Moyes AJ et al. (2019). C-Type Natriuretic Peptide (CNP) Regulates Adipogenesis, Thermogenesis and Glucose Sensitivity via Natriuretic Peptide Receptor (NPR)-C Signalling. American Heart Association

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71393
• Mitchell A, Alawi K, Aubdool A et al. (publicationYear). Intermittent cold exposure ameliorates fatty liver disease. nameOfConference

  
  

  DOI: 10.1530/endoabs.65.op3.1

  
  

  QMRO: qmroHref
• Dukinfield M, Maniati E, Reynolds LE et al. (2019). Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease. nameOfConference

  
  

  DOI: 10.1002/path.5340

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59784
• Moyes AJ, Chu SM, Aubdool AA et al. (2020). C-type natriuretic peptide co-ordinates cardiac structure and function. nameOfConference

  
  

  DOI: 10.1093/eurheartj/ehz093

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/56755
• Preedy ME, Baliga RS, Dukinfield MS et al. (2019). Inhibition of phosphodiesterase 2 reverses the development of heart failure by promoting NO/guanylyl cyclase/cGMP signalling. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Bubb KJ, Aubdool AA, Moyes AJ et al. (publicationYear). Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling.. nameOfConference

  
  

  DOI: 10.1161/CIRCULATIONAHA.118.036344

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/54649
• Kodji X, Arkless KL, Kee Z et al. (2019). Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis. nameOfConference

  
  

  DOI: 10.1096/fj.201800395rr

  
  

  QMRO: qmroHref
• Baliga RS, Preedy MEJ, Dukinfield MS et al. (2018). Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure.. nameOfConference

  
  

  DOI: 10.1073/pnas.1800996115

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/42747
• Pereira DMS, Mendes SJF, Alawi K et al. (2018). Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli‐Derived Thioredoxin Effects in Lipopolysaccharide‐Injected Mice. nameOfConference

  
  

  DOI: 10.1155/2018/4904696

  
  

  QMRO: qmroHref
• Barrese V, Stott JB, Figueiredo HB et al. (2018). Angiotensin II Promotes KV7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90). nameOfConference

  
  

  DOI: 10.1161/hypertensionaha.118.11116

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/42743
• Aubdool AA, Argunhan F, Thakore P et al. (2018). Response by Aubdool et al to Letters Regarding Article, “A Novel &agr;-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure”. nameOfConference

  
  

  DOI: 10.1161/circulationaha.117.031848

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/43644
• Pan Y, Thapa D, Baldissera L et al. (2018). Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature. nameOfConference

  
  

  DOI: 10.1007/s00424-017-2085-9

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/43088
• Wilde E, Aubdool AA, Thakore P et al. (2017). Tail-Cuff Technique and Its Influence on Central Blood Pressure in the Mouse.. nameOfConference

  
  

  DOI: 10.1161/JAHA.116.005204

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/43643
• Alawi K, Aubdool A, Liang L et al. (2017). Control of the sympathetic nervous system by TRPV1 in the regulation of body temperature. nameOfConference

  
  

  DOI: 10.1016/j.npep.2017.02.013

  
  

  QMRO: qmroHref
• Pinter E, Pozsgai G, Hajna Z et al. (2017). TRPA1 receptor-mediated effects of H2S donors and polysulfides. nameOfConference

  
  

  DOI: 10.1016/j.npep.2017.02.010

  
  

  QMRO: qmroHref
• Aubdool A, Brain S (2017). What is the relevance of vascular responses to CGRP?. nameOfConference

  
  

  DOI: 10.1016/j.npep.2017.02.007

  
  

  QMRO: qmroHref
• Aubdool AA, Thakore P, Argunhan F et al. (2017). A Novel &agr;-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure. nameOfConference

  
  

  DOI: 10.1161/circulationaha.117.028388

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/23185
• Aubdool AA, Kodji X, Brain SD (2017). Calcitonin Gene-Related Peptide (CGRP)☆. nameOfConference

  
  

  DOI: 10.1016/b978-0-12-801238-3.95757-x

  
  

  QMRO: qmroHref
• Aubdool AA, Bubb KJ, Moyes AJ et al. (2017). Endothelium-Derived C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodelling. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Srivastava S, Blower PJ, Aubdool AA et al. (2016). Cardioprotective effects of Cu((II))ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1.. nameOfConference

  
  

  DOI: 10.1038/s41598-016-0012-5

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/23057
• Kodji X, Aubdool AA, Brain SD (2016). Evidence for physiological and pathological roles for sensory nerves in the microvasculature and skin. nameOfConference

  
  

  DOI: 10.1016/j.retram.2016.09.002

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/23059
• Hajna Z, Sághy É, Payrits M et al. (2016). Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release. nameOfConference

  
  

  DOI: 10.1007/s12031-016-0802-z

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15560
• Alawi K, Russell FA, Aubdool AA et al. (2016). AB0095 Investigating The Role of Transient Receptor Potential Canonical 5 (TRPC5) in Complete Freund's Adjuvant (CFA)-Induced Arthritis. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2016-eular.3191

  
  

  QMRO: qmroHref
• Aubdool AA, Kodji X, Abdul-Kader N et al. (2016). TRPA1 activation leads to neurogenic vasodilatation: involvement of reactive oxygen nitrogen species in addition to CGRP and NO. nameOfConference

  
  

  DOI: 10.1111/bph.13519

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15432
• Alawi KM, Russell FA, Aubdool AA et al. (publicationYear). Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2015-208886

  
  

  QMRO: qmroHref
• Fernandes ES, Russell FA, Alawi KM et al. (2016). Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner. nameOfConference

  
  

  DOI: 10.1186/s13075-015-0905-x

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15356
• Alawi KM, Aubdool AA, Liang L et al. (2015). The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature. nameOfConference

  
  

  DOI: 10.1096/fj.15-272526

  
  

  QMRO: qmroHref
• Aubdool A (2015). The Young Life Scientists' Symposia 2014: Current Progress on the Physiology and Pharmacology of TRP Channels: 4 October 2014, King's College London, UK. nameOfConference

  
  

  DOI: 10.1042/bio03701036

  
  

  QMRO: qmroHref
• Aubdool A (2015). Young Life Scientists’ Symposium 2014. nameOfConference

  
  

  DOI: 10.36866/pn.97.18

  
  

  QMRO: qmroHref
• Aubdool AA, Graepel R, Kodji X et al. (publicationYear). TRPA1 is essential for the vascular response to environmental cold exposure. nameOfConference

  
  

  DOI: 10.1038/ncomms6732

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/17612
• Bodkin JV, Thakore P, Aubdool AA et al. (2014). Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension. nameOfConference

  
  

  DOI: 10.1002/prp2.52

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15222
• Aubdool A, Kodji X, Fernandes E et al. (2013). 190 THE PARTICIPATION OF REACTIVE OXYGEN SPECIES AND TRPA1 IN CINNAMALDEHYDE-INDUCED VASODILATATION IN THE PERIPHERAL VASCULATURE. nameOfConference

  
  

  DOI: 10.1136/heartjnl-2013-304019.190

  
  

  QMRO: qmroHref
• Graepel R, Aubdool AA, Kodji X et al. (2013). TRPA1 channels play a critical role in cold‐induced vasodilatation. nameOfConference

  
  

  DOI: 10.1096/fasebj.27.1_supplement.lb601

  
  

  QMRO: qmroHref
• Alexander R, Kerby A, Aubdool A et al. (2013). 4α‐phorbol 12,13‐didecanoate activates cultured mouse dorsal root ganglia neurons independently of TRPV4. nameOfConference

  
  

  DOI: 10.1111/j.1476-5381.2012.02186.x

  
  

  QMRO: qmroHref
• Fernandes ES, Vong CT, Quek S et al. (2013). Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B4‐induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1. nameOfConference

  
  

  DOI: 10.1096/fj.12-221218

  
  

  QMRO: qmroHref
• Aubdool AA, Brain SD (2011). Neurovascular Aspects of Skin Neurogenic Inflammation. nameOfConference

  
  

  DOI: 10.1038/jidsymp.2011.8

  
  

  QMRO: qmroHref
• Ryckmans T, Aubdool AA, Bodkin JV et al. (2011). Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel. nameOfConference

  
  

  DOI: 10.1016/j.bmcl.2011.06.035

  
  

  QMRO: qmroHref
• Graepel R, Fernandes ES, Aubdool AA et al. (2011). 4-Oxo-2-nonenal (4-ONE): Evidence of Transient Receptor Potential Ankyrin 1-Dependent and -Independent Nociceptive and Vasoactive Responses In Vivo. nameOfConference

  
  

  DOI: 10.1124/jpet.110.172403

  
  

  QMRO: qmroHref
• Aubdool AA, Graepel R, Brain SD (2011). A POTENTIAL LINK BETWEEN THE TRPA1 AND TRPV1 RECEPTORS IN VIVO. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref

Collaborators

Internal

• Professor Adrian Hobbs (QMUL)
• Professor Aung Oo (QMUL)

External

• Dr Janice Tsui (Royal Free Hospital)
• Professor Alan Daugherty (University of Kentucky)
• Dr Hong Lu (University of Kentucky)
• Professor Scott LeMaire (Baylor College of Medicine)

News

• Press release on publication of research
• https://www.moor.co.uk/support/gallery/
• https://www.prospects.ac.uk/case-studies/lecturer-in-cardiovascular-pharmacology-dr-aisah-a-aubdool