Professor Paul Charles EvansDean for Research Impact and Professor of Vascular MetabolismCentre: Biochemical PharmacologyEmail: paul.evans@qmul.ac.ukWebsite: https://www.paulevanslab.com/Twitter: @ProfPaulEvansProfileResearchPublicationsDisclosuresProfileProfessor Paul Evans is Professor of Vascular Metabolism at the William Harvey Research Institute, Queen Mary University of London. After completing his undergraduate studies at the University of Wales, Paul undertook training in molecular biology at the Babraham Institute in Cambridge before being appointed as a Senior Lecturer and then Reader at Imperial College London. He joined the University of Sheffield as Professor of Cardiovascular Science in 2011, and was recruited to QMUL in 2023. Paul's research has been published in more than 130 papers, and he has won several prestigious awards - most notably the European Society of Cardiology (ESC) Outstanding Achievement Award which is their highest award for scientific excellence. He is Chair-elect of the ESC Council for Basic Cardiovascular Science, working with more than 5000 cardiovascular scientists throughout Europe, and Vice Chair-elect of the Gordon Research Conference on Vascular Biomechanics scheduled for 2025.ResearchGroup members Dr Jovana Serbanovic-Canic (Research Fellow) - Jovana is a BHF Intermediate Basic Science Research Fellow investigating endothelial mechanoreceptors and how they regulate endothelial cell death in response to mechanical forces. She is using a range of different models and approaches to do this, including zebrafish, murine models and human cells. Dr Blanca Tardajos Ayllon (Postdoctoral Research Associate) - Blanca is a BHF-funded PostDoc working on the role of the TWIST1 gene in endothelial cell plasticity and atherosclerosis. Blanca recently completed her PhD in the lab, which focused on studying the role of the NFkB member C-Rel in shear stress mediated endothelial disfunction and atherosclerosis. Dr Siyu Tian (Postdoctoral Research Associate) - Siyu is an MRC-funded Postdoc working on the transcriptional control of atherosclerosis. Prior to taking up this post in the lab, Siyu completed her PhD at Erasmus MC, Rotterdam studying the PIEZO2 mechanosensor in pulmonary hypertension. Dr Mannekomba Diagbouga (Postdoctoral Research Associate) - Mannekomba is a BHF-funded PostDoc working on the role of the TWIST1 gene in endothelial cell plasticity and atherosclerosis. Prior to this Mannekomba was a PhD student in the laboratory of Professor Brenda Kwak in Geneva studying the influence of shear stress on intracranial aneurysms. Hazem Darwish (PhD Student) - Hazem is a first year PhD student developing novel inhibitors against a pro-atherogenic transcription factor. Priscila Hirschfeld (PhD Student) - Priscila is a first year PhD student funded by the BHF to study the role of NF-kB transcription factors in lipid metabolism and atherosclerosis. David Reid (PhD Student) - David is a first year PhD student funded by the A*STAR Institute in Singapore to study the role of TWIST1 in stroke. Summary Our research focuses on the biomechanical mechanisms that control atherosclerosis, a disease of arteries that can lead to angina, heart attack and stroke. Disturbed blood flow generates frictional forces (shear stress) that trigger pathophysiological changes in endothelial cells that promote atherosclerosis initiation and the progression of plaques into dangerous unstable forms prone to rupture or erosion. The laboratory combines genomics approaches with unbiased functional screening and biochemical studies to identify the signaling pathways and transcriptional programs that regulate endothelial cell responses to flow. The goal is to identify molecules within these pathways that can be targeted to prevent or treat atherosclerosis.The cross-disciplinary nature of our work has led to interactions with physicist and engineers as well as molecular and cellular biologists and clinical scientists.Publications Zhou Z, Korteland S-A, Tardajos-Ayllon B et al. (2024). Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaques. nameOfConference DOI: 10.1016/j.atherosclerosis.2024.118622 QMRO: qmroHref X S, Aitken C, Mehta V et al. (2024). Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing. nameOfConference DOI: 10.1242/jcs.262348 QMRO: qmroHref Pirri D, Tian S, Tardajos-Ayllon B et al. (2024). EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake. nameOfConference DOI: 10.1161/circresaha.123.324054 QMRO: qmroHref Zhao Y, Wang L, Huang Y et al. (publicationYear). Anthocyanins in Vascular Health and Disease: Mechanisms of Action and Therapeutic Potential. nameOfConference DOI: 10.1097/fjc.0000000000001602 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100350 Tian S, Evans PC (2024). BMPER regulates arterial adaptation to flow. nameOfConference DOI: 10.1038/s44161-024-00506-z QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100598 Xu M-Y, Xu J-J, Kang L-J et al. (2024). Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice. nameOfConference DOI: 10.1038/s41401-024-01317-5 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100791 Wagner R, Carré MJ, Perrault CM et al. (2024). Assessing friction and damage of cell monolayers on soft substrates in vitro. nameOfConference DOI: 10.1098/rsif.2023.0696 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100591 Wentzel JJ, Bos D, White SJ et al. (2024). Sex-related differences in coronary and carotid vessel geometry, plaque composition and shear stress obtained from imaging. nameOfConference DOI: 10.1016/j.atherosclerosis.2024.117616 QMRO: qmroHref Wei S, Wang L, Evans PC et al. (2024). NAFLD and NASH: etiology, targets and emerging therapies. nameOfConference DOI: 10.1016/j.drudis.2024.103910 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100667 Evans PC, Pearson J (2023). Editorial overview: Recent insights into the multifaceted physiology of the endothelial cell and its modulated functions in pathology. nameOfConference DOI: 10.1016/j.cophys.2023.100715 QMRO: qmroHref Alfaidi M, Evans PC, Pickering JG (publicationYear). Editorial: Endothelial-to-mesenchymal transition in cardiovascular disease. nameOfConference DOI: 10.3389/fcvm.2023.1290050 QMRO: qmroHref Tian S, Pirri D, Tardajos-Ayllon B et al. (2023). BS2 Flow-regulated EPAS1 limits atherosclerosis via metabolic control of endothelial proliferation. Basic Science DOI: 10.1136/heartjnl-2023-bcs.216 QMRO: qmroHref Tardajos-Ayllon B, Diagbouga M, Evans PC (2023). BS29 Endothelial TWIST1 enhances features of atherosclerotic plaque stability. Basic Science DOI: 10.1136/heartjnl-2023-bcs.242 QMRO: qmroHref (2023). Correction to: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. nameOfConference DOI: 10.1161/atv.0000000000000163 QMRO: qmroHref Li X, Souilhol C, Canham L et al. (2023). DLL4 promotes partial endothelial-to-mesenchymal transition at atherosclerosis-prone regions of arteries. nameOfConference DOI: 10.1016/j.vph.2023.107178 QMRO: qmroHref Canham L, Sendac S, Diagbouga MR et al. (2023). EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. nameOfConference DOI: 10.1161/atvbaha.122.318110 QMRO: qmroHref de Winther MPJ, Bäck M, Evans P et al. (2023). Translational opportunities of single-cell biology in atherosclerosis. nameOfConference DOI: 10.1093/eurheartj/ehac686 QMRO: qmroHref Souilhol C, Ayllon BT, Li X et al. (2022). JAG1-NOTCH4 mechanosensing drives atherosclerosis. nameOfConference DOI: 10.1126/sciadv.abo7958 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86842 Evans PC, Davidson SM, Wojta J et al. (2022). From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22. nameOfConference DOI: 10.1093/cvr/cvac114 QMRO: qmroHref Boldock L, Inzoli A, Bonardelli S et al. (publicationYear). Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. nameOfConference DOI: 10.1371/journal.pone.0271469 QMRO: qmroHref Zhou Z, Wu J, Wentzel J et al. (2022). BS21 Endothelial cell profile in responses to high shear stress is different in healthy arteries and plaques. Basic science DOI: 10.1136/heartjnl-2022-bcs.201 QMRO: qmroHref Chen Y, Evans PC, Wilkinson RN (2022). A Workflow to Track and Analyze Endothelial Migration During Vascular Development in Zebrafish Embryos Using Lightsheet Microscopy. nameOfConference DOI: 10.1007/978-1-0716-2059-5_2 QMRO: qmroHref Arbustini E, Behr ER, Carrier L et al. (2022). Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics. nameOfConference DOI: 10.1093/eurheartj/ehab895 QMRO: qmroHref Iqbal J, Chamberlain J, Alfaidi M et al. (2021). Carbon Monoxide Releasing Molecule A1 Reduces Myocardial Damage After Acute Myocardial Infarction in a Porcine Model. nameOfConference DOI: 10.1097/fjc.0000000000001067 QMRO: qmroHref Chiva-Blanch G, Evans PC (2021). Scientists on the Spot: A matter of blood flow. nameOfConference DOI: 10.1093/cvr/cvab320 QMRO: qmroHref Bowley G, Chico TJ, Serbanovic-Canic J et al. (publicationYear). Quantifying endothelial cell proliferation in the zebrafish embryo. nameOfConference DOI: 10.12688/f1000research.73130.1 QMRO: qmroHref Nataraj R, Hiwarkar P, Bonney D et al. (2022). B-cell depletion abrogates immune mediated cytopenia and rejection of cord blood transplantation in Hurler syndrome. nameOfConference DOI: 10.1038/s41409-021-01465-w QMRO: qmroHref Kugler E, Snodgrass R, Bowley G et al. (publicationYear). The effect of absent blood flow on the zebrafish cerebral and trunk vasculature. nameOfConference DOI: 10.1530/vb-21-0009 QMRO: qmroHref Davidson SM, Padró T, Bollini S et al. (2021). Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. nameOfConference DOI: 10.1093/cvr/cvab200 QMRO: qmroHref Evans P, Wojta J, Hoefer IE et al. (2021). Erratum to: The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics. nameOfConference DOI: 10.1093/cvr/cvab176 QMRO: qmroHref Kraler S, Libby P, Evans PC et al. (2021). Resilience of the Internal Mammary Artery to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs. nameOfConference DOI: 10.1161/atvbaha.121.316256 QMRO: qmroHref Ayllón BT, Souilhol C, Oakley F et al. (2021). A c-REL drives atherosclerosis at sites of disturbed blood flow. Young investigators award DOI: 10.1136/heartjnl-2021-bcs.235 QMRO: qmroHref Bowley G, Evans P, Serbanovic-Canic J et al. (2021). BS15 Using zebrafish embryos to identify genes that regulate endothelial proliferation. Basic science DOI: 10.1136/heartjnl-2021-bcs.213 QMRO: qmroHref Zhou Z, Van-Hateren N, Francis S et al. (2021). BS30 Light sheet imaging to analyse the spatial distribution of proteins in atherosclerotic plaques. Basic science DOI: 10.1136/heartjnl-2021-bcs.228 QMRO: qmroHref Bowley G, Kugler E, Wilkinson R et al. (2022). Zebrafish as a tractable model of human cardiovascular disease. nameOfConference DOI: 10.1111/bph.15473 QMRO: qmroHref Ward AO, Sala-Newby GB, Ladak S et al. (2022). Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells. nameOfConference DOI: 10.1177/02676591211012571 QMRO: qmroHref Evans P, Wojta J, Hoefer IE et al. (2021). The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics. nameOfConference DOI: 10.1093/cvr/cvab105 QMRO: qmroHref Wagner RMF, Maiti R, Carré MJ et al. (2021). Bio-tribology of Vascular Devices: A Review of Tissue/Device Friction Research. nameOfConference DOI: 10.1016/j.biotri.2021.100169 QMRO: qmroHref An W, Luong LA, Bowden NP et al. (2022). Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling. nameOfConference DOI: 10.1093/cvr/cvab056 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/70862 Wang M, Murdoch CE, Brewer AC et al. (2021). Endothelial NADPH oxidase 4 protects against angiotensin II‐induced cardiac fibrosis and inflammation. nameOfConference DOI: 10.1002/ehf2.13228 QMRO: qmroHref Evans PC, Fragiadaki M, Morris PD et al. (2021). Shear stress: the dark energy of atherosclerotic plaques. nameOfConference DOI: 10.1093/cvr/cvaa315 QMRO: qmroHref Ward AO, Angelini GD, Caputo M et al. (publicationYear). NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium. nameOfConference DOI: 10.1038/s41598-020-71781-6 QMRO: qmroHref Dweck MR, Maurovich-Horvat P, Leiner T et al. (2020). Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging. nameOfConference DOI: 10.1093/ehjci/jeaa201 QMRO: qmroHref Pirri D, Fragiadaki M, Evans PC (2020). Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors?. nameOfConference DOI: 10.1042/bsr20200026 QMRO: qmroHref Evans PC, Rainger GE, Mason JC et al. (2020). Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. nameOfConference DOI: 10.1093/cvr/cvaa230 QMRO: qmroHref Morris PD, Gosling R, Zwierzak I et al. (2021). A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease. nameOfConference DOI: 10.1093/cvr/cvaa220 QMRO: qmroHref Naase H, Harling L, Kidher E et al. (2020). Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass. nameOfConference DOI: 10.1186/s13019-020-01179-y QMRO: qmroHref Alexander Y, Osto E, Schmidt-Trucksäss A et al. (2021). Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis. nameOfConference DOI: 10.1093/cvr/cvaa085 QMRO: qmroHref Mahmoud MM, Serbanovic-Canic J, Feng S et al. (publicationYear). Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. nameOfConference DOI: 10.1038/s41598-020-60955-x QMRO: qmroHref Gomez I, Ward B, Souilhol C et al. (publicationYear). Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. nameOfConference DOI: 10.1038/s41467-019-14043-y QMRO: qmroHref Zun PS, Narracott AJ, Evans PC et al. (2020). A particle-based model for endothelial cell migration under flow conditions. nameOfConference DOI: 10.1007/s10237-019-01239-w QMRO: qmroHref Gijsen F, Katagiri Y, Barlis P et al. (2019). Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications.. nameOfConference DOI: 10.1093/eurheartj/ehz551 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/60081 Souilhol C, Gauci I, Feng S et al. (2020). Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites. nameOfConference DOI: 10.1093/cvr/cvz235 QMRO: qmroHref Souilhol C, Serbanovic-Canic J, Fragiadaki M et al. (2020). Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. nameOfConference DOI: 10.1038/s41569-019-0239-5 QMRO: qmroHref Ketelhuth DFJ, Lutgens E, Bäck M et al. (2019). Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. nameOfConference DOI: 10.1093/cvr/cvz166 QMRO: qmroHref Xanthis I, Souilhol C, Serbanovic-Canic J et al. (2019). β1 integrin is a sensor of blood flow direction. nameOfConference DOI: 10.1242/jcs.229542 QMRO: qmroHref Ayllón BT, Souilhol C, Oakley F et al. (2019). BS14 c-Rel drives atherosclerosis at sites of disturbed blood flow by activating inflammatory and proliferative transcriptional programmes in endothelium. Basic Science DOI: 10.1136/heartjnl-2019-bcs.177 QMRO: qmroHref Roddie H, Fragiadaki M, Evans P (2019). BS28 Endothelial STAT5A is enriched at atheroprone regions of the aorta and drives inflammation in response to low shear stress. Basic Science DOI: 10.1136/heartjnl-2019-bcs.191 QMRO: qmroHref Souilhol C, Canham L, Xueqi J et al. (2019). BS3 Notch ligand JAG1 promotes endothelial-to-mesenchymal transition and atherosclerosis at regions of disturbed flow. Basic Science DOI: 10.1136/heartjnl-2019-bcs.167 QMRO: qmroHref Serbanovic-Canic J, Souilhol C, Evans PC (2019). Shear stress makes its mark on the endothelial genome. nameOfConference DOI: 10.1093/cvr/cvz088 QMRO: qmroHref Baeriswyl DC, Prionisti I, Peach T et al. (2019). Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo.. nameOfConference DOI: 10.1038/s41598-019-40959-y QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58202 Mahmoud M, Souilhol C, Serbanovic-Canic J et al. (2019). GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis. nameOfConference DOI: 10.1007/s10557-019-06863-3 QMRO: qmroHref Fragiadaki M, Evans PC (2019). The Bernard and Joan Marshall Early Career Investigators and Distinguished Investigator Award 2018. nameOfConference DOI: 10.1007/s10557-018-6842-6 QMRO: qmroHref Tuñón J, Badimón L, Bochaton-Piallat M-L et al. (2019). Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology. nameOfConference DOI: 10.1093/cvr/cvy293 QMRO: qmroHref Weaver D, Densmore Z, Evans P (2018). Lessons Learned from Bacteria Monitoring and Treatment in Marcellus Production Operations. Day 3 Tue, October 09, 2018 DOI: 10.2118/191819-18erm-ms QMRO: qmroHref Xing R, Moerman AM, Ridwan RY et al. (publicationYear). The effect of the heart rate lowering drug Ivabradine on hemodynamics in atherosclerotic mice. nameOfConference DOI: 10.1038/s41598-018-32458-3 QMRO: qmroHref Caporali A, Bäck M, Daemen MJ et al. (2018). Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology. nameOfConference DOI: 10.1093/cvr/cvy184 QMRO: qmroHref Alfaidi MA, Chamberlain J, Rothman A et al. (2018). Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism. nameOfConference DOI: 10.1161/jaha.118.008757 QMRO: qmroHref Tuñón J, Bäck M, Badimón L et al. (2018). Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice. nameOfConference DOI: 10.1177/2047487318773384 QMRO: qmroHref Souilhol C, Evans PC (2018). Notching Up Vascular Inflammation. nameOfConference DOI: 10.1161/atvbaha.118.310856 QMRO: qmroHref Evans PC, Gijsen FJH, Wentzel JJ et al. (2016). Biomechanics in vascular biology and cardiovascular disease. nameOfConference DOI: 10.1160/th16-01-0075 QMRO: qmroHref Souilhol C, Harmsen MC, Evans PC et al. (2018). Endothelial–mesenchymal transition in atherosclerosis. nameOfConference DOI: 10.1093/cvr/cvx253 QMRO: qmroHref Feng S, Fragiadaki M, Souilhol C et al. (2017). Response by Feng et al to Letter Regarding Article, “Mechanical Activation of Hypoxia-Inducible Factor 1&agr; Drives Endothelial Dysfunction at Atheroprone Sites”. nameOfConference DOI: 10.1161/atvbaha.117.310341 QMRO: qmroHref Ridger VC, Boulanger CM, Angelillo-Scherrer A et al. (2017). Microvesicles in vascular homeostasis and diseases. nameOfConference DOI: 10.1160/th16-12-0943 QMRO: qmroHref Luong L, Duckles H, Schenkel T et al. (2016). Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries. nameOfConference DOI: 10.1160/th16-03-0214 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13776 Green JP, Souilhol C, Xanthis I et al. (2018). Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling. nameOfConference DOI: 10.1093/cvr/cvx213 QMRO: qmroHref Feng S, Bowden N, Fragiadaki M et al. (2017). Mechanical Activation of Hypoxia-Inducible Factor 1&agr; Drives Endothelial Dysfunction at Atheroprone Sites. nameOfConference DOI: 10.1161/atvbaha.117.309249 QMRO: qmroHref Mahmoud MM, Serbanovic-Canic J, Feng S et al. (publicationYear). Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. nameOfConference DOI: 10.1038/s41598-017-03532-z QMRO: qmroHref Mann P, Khamis RY, Haskard D et al. (2017). 169 Developing capture assays to measure circulating crp/oxidised low density lipoprotein complexes in patients undergoing cardiopulmonary bypass and examining use of crp/oxidised low density lipoprotein complexes as a biomarker of atherosclerosis. nameOfConference DOI: 10.1136/heartjnl-2017-311726.167 QMRO: qmroHref Nguyen BA, McDonald G, Fiorentino F et al. (publicationYear). Consumption of Broccoli Sprouts Attenuates Intracellular P38 Map Kinase and Reactive Oxygen Species Pro-Inflammatory Activation in Human Leukocytes: A Randomised- Controlled Trial. nameOfConference DOI: 10.4172/2472-1921.100060 QMRO: qmroHref Serbanovic-Canic J, de Luca A, Warboys C et al. (2016). Zebrafish Model for Functional Screening of Flow-Responsive Genes.. nameOfConference DOI: 10.1161/ATVBAHA.116.308502 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/49547 Nguyen B, Reeves B, Angelini G et al. (2016). Reply. nameOfConference DOI: 10.1016/j.athoracsur.2016.04.088 QMRO: qmroHref Hsiao ST, Spencer T, Boldock L et al. (2016). Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase. nameOfConference DOI: 10.1093/cvr/cvw210 QMRO: qmroHref Halliday I, Lishchuk SV, Spencer TJ et al. (2016). Local membrane length conservation in two-dimensional vesicle simulation using a multicomponent lattice Boltzmann equation method. nameOfConference DOI: 10.1103/physreve.94.023306 QMRO: qmroHref Holloway PM, Gillespie S, Becker F et al. (2016). Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways. nameOfConference DOI: 10.1016/j.vph.2016.07.004 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/22393 Green J, Evans P, Wilson H (2016). 191 Atheroprone Flow Alters ATP-Induced Calcium Signalling in the Endothelium. nameOfConference DOI: 10.1136/heartjnl-2016-309890.191 QMRO: qmroHref Bowden N, Feng S, Francis S et al. (2016). 211 Non-Canonical NF-Κb Signalling Promotes Endothelial Proliferation in Response to Low Wall Shear Stress. nameOfConference DOI: 10.1136/heartjnl-2016-309890.211 QMRO: qmroHref Mahmoud MM, Kim HR, Xing R et al. (2016). TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. nameOfConference DOI: 10.1161/circresaha.116.308870 QMRO: qmroHref Bowden N, Bryan MT, Duckles H et al. (2016). Experimental Approaches to Study Endothelial Responses to Shear Stress. nameOfConference DOI: 10.1089/ars.2015.6553 QMRO: qmroHref Brown AJ, Teng Z, Evans PC et al. (2016). Role of biomechanical forces in the natural history of coronary atherosclerosis. nameOfConference DOI: 10.1038/nrcardio.2015.203 QMRO: qmroHref Maguire R, Duckles H, Evans PC et al. (2016). How does blood flow regulate vascular notch signalling?. nameOfConference DOI: 10.1016/j.atherosclerosis.2015.10.076 QMRO: qmroHref Nguyen BAV, Fiorentino F, Reeves BC et al. (2016). Mini Bypass and Proinflammatory Leukocyte Activation: A Randomized Controlled Trial. nameOfConference DOI: 10.1016/j.athoracsur.2015.09.029 QMRO: qmroHref Morris PD, Narracott A, von Tengg-Kobligk H et al. (2016). Computational fluid dynamics modelling in cardiovascular medicine. nameOfConference DOI: 10.1136/heartjnl-2015-308044 QMRO: qmroHref Di Marco LY, Venneri A, Farkas E et al. (2015). Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles. nameOfConference DOI: 10.1016/j.nbd.2015.08.014 QMRO: qmroHref Green J, Wilson H, Evans P (2015). 185 Shear Stress Dependent Regulation of p2x4 and p2x7 Receptors in the Endothelium. nameOfConference DOI: 10.1136/heartjnl-2015-308066.185 QMRO: qmroHref Alfaidi M, Schenkel T, Evans P et al. (2015). 192 Dietary Docosahexaenoic Acid Reduced Experimental Atherosclerosis by Inducing Protective Haemodynamic Conditions. nameOfConference DOI: 10.1136/heartjnl-2015-308066.192 QMRO: qmroHref Mahmoud M, Kim R, Hsiao S et al. (2015). 204 Disturbed Flow Promotes Atherogenesis through the Activation of Endothelial-Mesenchymal Transition. nameOfConference DOI: 10.1136/heartjnl-2015-308066.204 QMRO: qmroHref Bryan M, Xanthis I, Hsiao S et al. (2015). 206 Using Magnetic Tweezers to probe Mechanically-Induced Signalling in Endothelial Cells. nameOfConference DOI: 10.1136/heartjnl-2015-308066.206 QMRO: qmroHref Gomez I, Ward B, Evans P et al. (2015). YIA2 Neutrophil Microvesicles Influence Atherogenesis and Contain Mirna. nameOfConference DOI: 10.1136/heartjnl-2015-308066.225 QMRO: qmroHref Hoefer IE, Steffens S, Ala-Korpela M et al. (2015). Novel methodologies for biomarker discovery in atherosclerosis. nameOfConference DOI: 10.1093/eurheartj/ehv236 QMRO: qmroHref Evans P, Nederlof E, Richmond W (2015). Souring Development Associated with PWRI in a North Sea Field. All Days DOI: 10.2118/174529-ms QMRO: qmroHref Gomez I, Ward B, Evans P et al. (2015). Abstract 558: Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis. nameOfConference DOI: 10.1161/atvb.35.suppl_1.558 QMRO: qmroHref Kidher E, Jarral OA, Harling L et al. (2015). NR2 antibody is associated with quality of life in aortic valve replacement. nameOfConference DOI: 10.1177/0218492315583189 QMRO: qmroHref Mylroie H, Dumont O, Bauer A et al. (2015). PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis. nameOfConference DOI: 10.1093/cvr/cvv131 QMRO: qmroHref Enesa K, Moll HP, Luong L et al. (2015). A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes. nameOfConference DOI: 10.1096/fj.14-258533 QMRO: qmroHref Bowden N, Duckles H, Mahmoud M et al. (2014). Disturbed flow induces expression of the negative NF-kappaB regulator Cezanne. nameOfConference DOI: 10.1016/j.atherosclerosis.2014.10.032 QMRO: qmroHref Gauci I, Mahmoud M, Duckles H et al. (2014). Disturbed flow influences endothelial activation by inducing homeobox transcription factors. nameOfConference DOI: 10.1016/j.atherosclerosis.2014.10.053 QMRO: qmroHref Mahmoud M, Hsiao S, Gauci I et al. (2014). GATA4 promotes endothelial cell turnover at regions of arteries exposed to disturbed flow. nameOfConference DOI: 10.1016/j.atherosclerosis.2014.10.035 QMRO: qmroHref Duckles H, Mahmoud M, Hsiao S et al. (2014). Identification of a molecular switch controlling the induction of senescence or quiescence by flow. nameOfConference DOI: 10.1016/j.atherosclerosis.2014.10.051 QMRO: qmroHref Kwak BR, Bäck M, Bochaton-Piallat M-L et al. (2014). Biomechanical factors in atherosclerosis: mechanisms and clinical implications†. nameOfConference DOI: 10.1093/eurheartj/ehu353 QMRO: qmroHref Li J, Hou B, Tumova S et al. (2014). Piezo1 integration of vascular architecture with physiological force. nameOfConference DOI: 10.1038/nature13701 QMRO: qmroHref Cuhlmann S, Gsell W, Van der Heiden K et al. (2014). In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106. nameOfConference DOI: 10.2310/7290.2014.00014 QMRO: qmroHref Hsiao S, Tovar-Lopez F, Gunn J et al. (2014). 292Endothelial cell forward migration in a disturbed wall shear stress environment is promoted by ROCK inhibition. nameOfConference DOI: 10.1093/cvr/cvu087.6 QMRO: qmroHref Mahmoud M, Kim R, De Luca A et al. (2014). P470Disturbed flow promotes endothelial cell injury via the induction of developmental genes. nameOfConference DOI: 10.1093/cvr/cvu091.147 QMRO: qmroHref Bryan MT, Duckles H, Feng S et al. (2014). Mechanoresponsive Networks Controlling Vascular Inflammation. nameOfConference DOI: 10.1161/atvbaha.114.303424 QMRO: qmroHref Kidher E, Harling L, Ashrafian H et al. (2014). Aortic stiffness as a marker of cardiac function and myocardial strain in patients undergoing aortic valve replacement. nameOfConference DOI: 10.1186/1749-8090-9-102 QMRO: qmroHref Nguyen BAV, Suleiman M-S, Anderson JR et al. (2014). Metabolic derangement and cardiac injury early after reperfusion following intermittent cross-clamp fibrillation in patients undergoing coronary artery bypass graft surgery using conventional or miniaturized cardiopulmonary bypass. nameOfConference DOI: 10.1007/s11010-014-2122-3 QMRO: qmroHref Kidher E, Harling L, Sugden C et al. (2014). Aortic stiffness is an indicator of cognitive dysfunction before and after aortic valve replacement for aortic stenosis. nameOfConference DOI: 10.1093/icvts/ivu194 QMRO: qmroHref Amini N, Boyle JJ, Moers B et al. (2014). Requirement of JNK1 for endothelial cell injury in atherogenesis. nameOfConference DOI: 10.1016/j.atherosclerosis.2014.05.950 QMRO: qmroHref Mahmoud M, Kim R, de Luca A et al. (2014). 189 Disturbed Flow Promotes Endothelial Cell Injury Via the Induction of Developmental Genes. nameOfConference DOI: 10.1136/heartjnl-2014-306118.189 QMRO: qmroHref Gauci I, Luong L, Mahmoud M et al. (2014). 192 The Induction of Homeobox Genes by Disturbed Flow Limits Inflammation at Atherosusceptible Sites. nameOfConference DOI: 10.1136/heartjnl-2014-306118.192 QMRO: qmroHref Hsiao S, Tovar F, Gunn J et al. (2014). 219 Rock Inhibits Endothelial Migration in Disturbed flow Condition: A Potential Therapeutic Target in PCI. nameOfConference DOI: 10.1136/heartjnl-2014-306118.219 QMRO: qmroHref Luong L, Duckles H, Schenkel T et al. (2014). Abstract 258: A Pharmacological Approach to Promote Shear Stress-Dependent Anti-inflammatory Mechanisms in Arteries. nameOfConference DOI: 10.1161/atvb.34.suppl_1.258 QMRO: qmroHref Mahmoud M, Kim R, de Luca A et al. (2014). Abstract 266: Disturbed Flow Promotes Endothelial Cell Injury via the Induction of Developmental Genes. nameOfConference DOI: 10.1161/atvb.34.suppl_1.266 QMRO: qmroHref Hsiao S, Tovar-Lopez F, Gunn J et al. (2014). Abstract 521: Endothelial Cell Forward Migration in a Disturbed Wall Shear Stress Environment is Promoted by Rho-Kinase Inhibition. nameOfConference DOI: 10.1161/atvb.34.suppl_1.521 QMRO: qmroHref Enesa K, Evans P (2014). The Biology of A20-Like Molecules. nameOfConference DOI: 10.1007/978-1-4939-0398-6_3 QMRO: qmroHref Warboys CM, de Luca A, Amini N et al. (2014). Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway. nameOfConference DOI: 10.1161/atvbaha.114.303415 QMRO: qmroHref Nguyen B, Luong L, Naase H et al. (2014). Sulforaphane pretreatment prevents systemic inflammation and renal injury in response to cardiopulmonary bypass. nameOfConference DOI: 10.1016/j.jtcvs.2013.12.048 QMRO: qmroHref Bovens SM, Foin N, O'Clery N et al. (2013). Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells. nameOfConference DOI: 10.1093/eurheartj/eht307.p582 QMRO: qmroHref Wells RE, Barry JD, Warrington SJ et al. (2013). Control of tissue morphology by Fasciclin III-mediated intercellular adhesion. nameOfConference DOI: 10.1242/dev.096214 QMRO: qmroHref De Luca A, Warboys CM, Amini N et al. (2012). Image-Based Computational Hemodynamics and Microarray Analysis of the Porcine Aortic Arch Reveals a Correlation Between Shear Stress and Endothelial Cell Apoptosis. ASME 2012 Summer Bioengineering Conference, Parts A and B DOI: 10.1115/sbc2012-80948 QMRO: qmroHref Van der Heiden K, Groen HC, Evans PC et al. (2012). Non-Invasive Molecular Imaging of Shear Stress-Induced Endothelial Activation and Atherosclerotic Plaque Vulnerability. ASME 2012 Summer Bioengineering Conference, Parts A and B DOI: 10.1115/sbc2012-80515 QMRO: qmroHref Evans PC, Kwak BR (2013). Biomechanical factors in cardiovascular disease. nameOfConference DOI: 10.1093/cvr/cvt143 QMRO: qmroHref De Luca A, Warboys C, Amini N et al. (2013). 170 TRANSCRIPTOME PROFILING IN PORCINE ARTERIES TO IDENTIFY NOVEL SHEAR-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL FATE. nameOfConference DOI: 10.1136/heartjnl-2013-304019.170 QMRO: qmroHref Serbanovic-Canic J, de Luca A, Warboys C et al. (2013). YIA4: IDENTIFICATION OF NOVEL SHEAR STRESS-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL DYSFUNCTION USING THE ZEBRAFISH MODEL. nameOfConference DOI: 10.1136/heartjnl-2013-304019.271 QMRO: qmroHref Van der Heiden K, Gijsen FJH, Narracott A et al. (2013). The effects of stenting on shear stress: relevance to endothelial injury and repair. nameOfConference DOI: 10.1093/cvr/cvt090 QMRO: qmroHref Haskard DO, Boyle JJ, Evans PC et al. (2013). Cytoprotective Signaling and Gene Expression in Endothelial Cells and Macrophages—Lessons for Atherosclerosis. nameOfConference DOI: 10.1111/micc.12020 QMRO: qmroHref Luong LA, Fragiadaki M, Smith J et al. (2013). Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination. nameOfConference DOI: 10.1161/circresaha.111.300119 QMRO: qmroHref Gray C, Bratt D, Lees J et al. (2013). Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development. nameOfConference DOI: 10.1161/atvbaha.112.300590 QMRO: qmroHref Bovens SM, Foin N, O'Clery N et al. (2013). Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells. nameOfConference DOI: doi QMRO: qmroHref Warboys CM, de Luca A, Amini N et al. (2012). The influence of flow on vascular endothelial cell senescence. nameOfConference DOI: 10.1016/j.atherosclerosis.2012.10.021 QMRO: qmroHref Golubnitschaja O, Costigliola V, EPMA (2012). General Report & Recommendations in Predictive, Preventive and Personalised Medicine 2012: White Paper of the European Association for Predictive, Preventive and Personalised Medicine. nameOfConference DOI: 10.1186/1878-5085-3-14 QMRO: qmroHref Nayak A, König CS, Kishore U et al. (2013). Regulation of Endothelial Activation and Vascular Inflammation by Shear Stress. nameOfConference DOI: 10.1007/978-1-4614-4376-6_6 QMRO: qmroHref Dumont O, Mylroie H, Bauer A et al. (2012). Protein kinase Cϵ activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-κB-dependent pathway to enhance vascular protection. nameOfConference DOI: 10.1042/bj20120574 QMRO: qmroHref Boyle JJ, Christou I, Iqbal MB et al. (2012). Solid-Phase Immunoglobulins IgG and IgM Activate Macrophages with Solid-Phase IgM Acting via a Novel Scavenger Receptor A Pathway. nameOfConference DOI: 10.1016/j.ajpath.2012.03.040 QMRO: qmroHref Pfenniger A, Wong C, Sutter E et al. (2012). Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells. nameOfConference DOI: 10.1016/j.yjmcc.2012.05.011 QMRO: qmroHref Kuhlmann MT, Cuhlmann S, Hoppe I et al. (publicationYear). Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice. nameOfConference DOI: 10.3791/3308-v QMRO: qmroHref Kuhlmann MT, Cuhlmann S, Hoppe I et al. (publicationYear). Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice.. nameOfConference DOI: 10.3791/3308 QMRO: qmroHref Boyle JJ, Johns M, Lo J et al. (2011). Heme Induces Heme Oxygenase 1 via Nrf2. nameOfConference DOI: 10.1161/atvbaha.111.225813 QMRO: qmroHref Vossenkämper A, Marchès O, Fairclough PD et al. (2011). Inhibition of NF-kB signaling in human dendritic cells the enterpathogenic Escherichia coli effector protein NIeE. nameOfConference DOI: 10.4049/jimmunol.1000500 QMRO: qmroHref Luong LA, Evans PC (2011). Targeting Inhibitor of Apoptosis Proteins to Block Vascular Inflammation. nameOfConference DOI: 10.1161/atvbaha.111.235762 QMRO: qmroHref Harling L, Warren OJ, Martin A et al. (2011). Do Miniaturized Extracorporeal Circuits Confer Significant Clinical Benefit Without Compromising Safety? A Meta-Analysis of Randomized Controlled Trials. nameOfConference DOI: 10.1097/mat.0b013e318209d63b QMRO: qmroHref Zuluaga E, Evans P, Nesom P et al. (2011). Technical Evaluations To Support the Decision To Reinject Produced Water. nameOfConference DOI: 10.2118/132346-pa QMRO: qmroHref Warboys CM, Amini N, de Luca A et al. (2011). The role of blood flow in determining the sites of atherosclerotic plaques. nameOfConference DOI: 10.3410/m3-5 QMRO: qmroHref Cuhlmann S, Van der Heiden K, Saliba D et al. (2011). Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1. nameOfConference DOI: 10.1161/circresaha.110.233841 QMRO: qmroHref Evans PC (2011). The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease. nameOfConference DOI: 10.1007/s13167-011-0064-3 QMRO: qmroHref Warboys CM, Amini N, Luca AD et al. (2011). When stress is good. nameOfConference DOI: doi QMRO: qmroHref Zakkar M, Luong LA, Chaudhury H et al. (2011). Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1. nameOfConference DOI: 10.1161/circulationaha.110.979542 QMRO: qmroHref Gsell W, Cuhlmann S, Van der Heiden K et al. (2011). 18FEDAA is a more specific probe than 18FDG for imaging vascular inflammation. nameOfConference DOI: doi QMRO: qmroHref Pfenniger A, Sutter E, Cuhlmann S et al. (2011). Endothelial Cx37 expression is regulated by the shear stress responsive transcription factor KLF2. nameOfConference DOI: doi QMRO: qmroHref Sperone A, Dryden N, Birdsey GM et al. (2010). The transcription factor Erg represses ICAM-1 expression and vascular inflammation. nameOfConference DOI: 10.1016/j.atherosclerosis.2010.08.039 QMRO: qmroHref Halliday I, Atherton M, Care CM et al. (2011). Multi-scale interaction of particulate flow and the artery wall. nameOfConference DOI: 10.1016/j.medengphy.2010.09.007 QMRO: qmroHref Sperone A, Dryden NH, Birdsey GM et al. (2011). The Transcription Factor Erg Inhibits Vascular Inflammation by Repressing NF-&kgr;B Activation and Proinflammatory Gene Expression in Endothelial Cells. nameOfConference DOI: 10.1161/atvbaha.110.216473 QMRO: qmroHref Zuluaga E, Evans P, Nesom P et al. (2010). Technical Evaluations to Support the Decision to Reinject Produced Water. SPE Annual Technical Conference and Exhibition DOI: 10.2118/132346-ms QMRO: qmroHref Cuhlmann S, van der Heiden K, Zakkar M et al. (2010). YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF-κB transcription factors. nameOfConference DOI: 10.1136/hrt.2010.205781.4 QMRO: qmroHref Jevon M, Ansari TI, Finch J et al. (2011). Smooth muscle cells in porcine vein graft intimal hyperplasia are derived from the local vessel wall. nameOfConference DOI: 10.1016/j.carpath.2010.04.003 QMRO: qmroHref van der Heiden K, Cuhlmann S, Luong LA et al. (2010). Role of nuclear factor κB in cardiovascular health and disease. nameOfConference DOI: 10.1042/cs20090557 QMRO: qmroHref Hamdulay SS, Wang B, Birdsey GM et al. (2010). Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium. nameOfConference DOI: 10.1016/j.freeradbiomed.2010.01.017 QMRO: qmroHref Chaudhury H, Zakkar M, Boyle J et al. (2010). c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis. nameOfConference DOI: 10.1161/atvbaha.109.201368 QMRO: qmroHref Pfenniger A, Galan K, Wong C et al. (2010). Shear Stress Modulates the Expression of the Vasoprotective Protein Cx37 in Endothelial Cells. nameOfConference DOI: doi QMRO: qmroHref Krams R, Cuhlmann S, Foin N et al. (2010). Shear stress, inflammation and Atherosclerosis. nameOfConference DOI: 10.1016/j.artres.2010.03.002 QMRO: qmroHref Amirak E, Zakkar M, Evans PC et al. (2010). Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells. nameOfConference DOI: 10.1016/j.bbrc.2009.11.145 QMRO: qmroHref Zakkar M, Van der Heiden K, Luong LA et al. (2009). Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State. nameOfConference DOI: 10.1161/atvbaha.109.193375 QMRO: qmroHref Evans P (2008). Reservoir Souring Modelling, Prediction and Mitigation. Volume 5: Materials Technology; CFD and VIV DOI: 10.1115/omae2008-57085 QMRO: qmroHref Ali F, Zakkar M, Karu K et al. (2009). Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow*. nameOfConference DOI: 10.1074/jbc.m109.009886 QMRO: qmroHref Evans PC (2009). Nur77. nameOfConference DOI: 10.1161/circresaha.109.195529 QMRO: qmroHref Zakkar M, van der Heiden K, Chaudhury H et al. (2009). ACTIVATION OF NF-E2 RELATED FACTOR-2 (NRF2) PROTECTS ARTERIES FROM EXHIBITING A PRO-INFLAMMATORY STATE. nameOfConference DOI: 10.1136/hrt.2009.181669m QMRO: qmroHref Chaudhury HA, Zakkar M, Boyle J et al. (2009). ENDOTHELIAL CELLS AT ATHEROSUSCEPTIBLE SITES EXPRESS ACTIVATED C-JUN N-TERMINAL KINASE WHICH INDUCES PRO-APOPTOTIC MOLECULES. nameOfConference DOI: 10.1136/hrt.2009.178137f QMRO: qmroHref Cuhlmann S, van der Heiden K, Zakkar M et al. (2009). HIGH SHEAR STRESS SUPPRESSES THE EXPRESSION AND ACTIVITY OF NF-KAPPAB TRANSCRIPTION FACTORS IN ARTERIAL ENDOTHELIUM. nameOfConference DOI: 10.1136/hrt.2009.178137h QMRO: qmroHref Foin N, Plata-Garcia A, Cuhlmann S et al. (2009). SHEAR STRESS AND NITRIC OXIDE TRANSPORT AFFECT NF-KB DYNAMICS IN ENDOTHELIAL CELLS. nameOfConference DOI: 10.1136/hrt.2009.178137m QMRO: qmroHref Foin N, Plata-Garcia A, Qin Q et al. (2009). Shear Stress and Nitric Oxide Transport Affect NF-κB Dynamics In Endothelial Cells. nameOfConference DOI: doi QMRO: qmroHref Evans PC (2008). Effects of shear stress on endothelial activation and vascular inflammation. nameOfConference DOI: 10.1016/j.biopha.2008.07.033 QMRO: qmroHref Lutz J, Luong LA, Strobl M et al. (2008). The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. nameOfConference DOI: 10.1007/s00109-008-0405-4 QMRO: qmroHref Zakkar M, Chaudhury H, Sandvik G et al. (2008). Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis. nameOfConference DOI: 10.1161/circresaha.108.183913 QMRO: qmroHref Ridger V, Krams R, Carpi A et al. (2008). Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update. nameOfConference DOI: 10.1016/j.biopha.2008.07.053 QMRO: qmroHref Zakkar M, Chaudhury H, Krams R et al. (2008). MAP KINASE PHOSPHATASE-1 SUPPRESSES ENDOTHELIAL ACTIVATION IN REGIONS OF THE ARTERIAL TREE THAT ARE RESISTANT TO ATHEROSCLEROSIS. nameOfConference DOI: 10.1016/j.atherosclerosis.2008.05.006 QMRO: qmroHref Enesa K, Ito K, Le A. Luong et al. (2008). Hydrogen Peroxide Prolongs Nuclear Localization of NF-κB in Activated Cells by Suppressing Negative Regulatory Mechanisms*. nameOfConference DOI: 10.1074/jbc.m801312200 QMRO: qmroHref Birks EJ, Latif N, Enesa K et al. (2008). Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy. nameOfConference DOI: 10.1093/cvr/cvn083 QMRO: qmroHref Kinderlerer AR, Ali F, Johns M et al. (2008). KLF2-dependent, Shear Stress-induced Expression of CD59. nameOfConference DOI: 10.1074/jbc.m800362200 QMRO: qmroHref Mason JC, Kinderlerer A, Ali F et al. (2008). KLF‐2‐dependent, shear stress‐induced expression of CD59: a novel cytoprotective mechanism against complement‐mediated injury in the vasculature. nameOfConference DOI: 10.1096/fasebj.22.1_supplement.471.2 QMRO: qmroHref Foin N, Evans P, Krams R (2008). Atherosclerosis: cell biology and lipoproteins – new developments in imaging of inflammation of the vulnerable plaque. nameOfConference DOI: 10.1097/mol.0b013e3282f41b60 QMRO: qmroHref Enesa K, Zakkar M, Chaudhury H et al. (2008). NF-κB Suppression by the Deubiquitinating Enzyme Cezanne A NOVEL NEGATIVE FEEDBACK LOOP IN PRO-INFLAMMATORY SIGNALING*. nameOfConference DOI: 10.1074/jbc.m708690200 QMRO: qmroHref Zakkar M, Chaudhury H, Punjabi PP et al. (2008). Acute high shear stress activates venous but not arterial endothelial cells by signalling through the p38 MAP kinase pathway. nameOfConference DOI: doi QMRO: qmroHref Helderman F, Segers D, de Crom R et al. (2007). Effect of shear stress on vascular inflammation and plaque development. nameOfConference DOI: 10.1097/mol.0b013e3282ef7716 QMRO: qmroHref Evans KEAPC (2007). Chains of command: Ubiquitin in proinflammatory signalling. nameOfConference DOI: 10.1042/bio02904024 QMRO: qmroHref Partridge J, Carlsen H, Enesa K et al. (2007). Laminar shear stress acts as a switch to regulate divergent functions of NF‐κB in endothelial cells. nameOfConference DOI: 10.1096/fj.06-8059com QMRO: qmroHref Adcock I, Evans PC (2007). Resolution of Inflammatory Responses: a brief introduction. nameOfConference DOI: 10.1042/bst0350261 QMRO: qmroHref Partridge J, Enesa K, Kinderlerer A et al. (2007). Shear stress modulates endothelial responses to TNFα by suppressing proinflammatory transcripts and enhancing cytoprotective transcripts. nameOfConference DOI: doi QMRO: qmroHref Evans P, Dunsmore B (2006). Reservoir simulation of sulfate-reducing bacteria activity in the deep sub-surface. nameOfConference DOI: doi QMRO: qmroHref Marques C, Guo W, Pereira P et al. (2006). The triage of damaged proteins: degradation by the ubiquitin‐proteasome pathway or repair by molecular chaperones. nameOfConference DOI: 10.1096/fj.05-5080fje QMRO: qmroHref Evans PC (2005). Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs. nameOfConference DOI: 10.1017/s1462399405009415 QMRO: qmroHref Goodman RS, Ewing J, Evans PC et al. (2005). Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation. nameOfConference DOI: 10.1038/sj.bmt.1705013 QMRO: qmroHref EVANS PC, Huib O, HAMON M et al. (2004). Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. nameOfConference DOI: 10.1042/bj20031377 QMRO: qmroHref Evans PC, Smith TS, Lai M-J et al. (2003). A Novel Type of Deubiquitinating Enzyme*. nameOfConference DOI: 10.1074/jbc.m301863200 QMRO: qmroHref Evans PC, Taylor ER, Coadwell J et al. (2001). Isolation and characterization of two novel A20-like proteins.. nameOfConference DOI: 10.1042/0264-6021:3570617 QMRO: qmroHref EVANS PC, TAYLOR ER, COADWELL J et al. (2001). Isolation and characterization of two novel A20-like proteins. nameOfConference DOI: 10.1042/bj3570617 QMRO: qmroHref Corps E, Carter C, Karecla P et al. (2001). Recognition of E-cadherin by Integrin αEβ7 REQUIREMENT FOR CADHERIN DIMERIZATION AND IMPLICATIONS FOR CADHERIN AND INTEGRIN FUNCTION*. nameOfConference DOI: 10.1074/jbc.m101712200 QMRO: qmroHref Evans PC, Smith S, Hirschfield G et al. (2001). Recipient HLA-DR3, tumour necrosis factor-α promoter allele-2 (tumour necrosis factor-2) and cytomegalovirus infection are inter-related risk factors for chronic rejection of liver grafts. nameOfConference DOI: 10.1016/s0168-8278(00)00101-x QMRO: qmroHref Evans PC, Taylor ER, Kilshaw PJ (2001). SIGNALING THROUGH CD31 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS. nameOfConference DOI: 10.1097/00007890-200102150-00020 QMRO: qmroHref Buckley CD (2001). Signaling Through CD31 Protects Endothelial Cells from Apoptosis. Transplantation 2001; 71: 457.. nameOfConference DOI: 10.1097/00007890-200102150-00001 QMRO: qmroHref Evans PC, Kilshaw PJ (2000). INTERLEUKIN-13 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS AND ACTIVATION. nameOfConference DOI: 10.1097/00007890-200009270-00010 QMRO: qmroHref Lambert NC, Evans PC, Hashizumi TL et al. (2000). Cutting Edge: Persistent Fetal Microchimerism in T Lymphocytes Is Associated with HLA-DQA1*0501: Implications in Autoimmunity. nameOfConference DOI: 10.4049/jimmunol.164.11.5545 QMRO: qmroHref Evans PC, Soin A, Wreghitt TG et al. (2000). AN ASSOCIATION BETWEEN CYTOMEGALOVIRUS INFECTION AND CHRONIC REJECTION AFTER LIVER TRANSPLANTATION. nameOfConference DOI: 10.1097/00007890-200001150-00007 QMRO: qmroHref EVANS PC, GRAY JJ, WREGHITT TG et al. (1999). Comparison of three PCR techniques for detecting cytomegalovirus (CMV) DNA in serum, detection of early antigen fluorescent foci and culture for the diagnosis of CMV infection. nameOfConference DOI: 10.1099/00222615-48-11-1029 QMRO: qmroHref Evans PC, Coleman N, Wreghitt TG et al. (1999). Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts. nameOfConference DOI: 10.1016/s0168-8278(99)80294-3 QMRO: qmroHref Nasu K, Whyte A, Green SJ et al. (1999). α-GALACTOSYL-MEDIATED ACTIVATION OF PORCINE ENDOTHELIAL CELLS. nameOfConference DOI: 10.1097/00007890-199909270-00020 QMRO: qmroHref Maloney S, Smith A, Furst DE et al. (1999). Microchimerism of maternal origin persists into adult life. nameOfConference DOI: 10.1172/jci6611 QMRO: qmroHref Evans PC, Lambert N, Maloney S et al. (1999). Long-Term Fetal Microchimerism in Peripheral Blood Mononuclear Cell Subsets in Healthy Women and Women With Scleroderma. nameOfConference DOI: 10.1182/blood.v93.6.2033.406k18_2033_2037 QMRO: qmroHref Evans PC, Soin A, Wreghitt TG et al. (1998). Qualitative and semiquantitative polymerase chain reaction testing for cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients.. nameOfConference DOI: 10.1136/jcp.51.12.914 QMRO: qmroHref Evans PC, Gray J, Wreghitt TG et al. (1998). Optimisation of the polymerase chain reaction and dot-blot hybridisation for detecting cytomegalovirus DNA in urine: comparison with detection of early antigen fluorescent foci and culture. nameOfConference DOI: 10.1016/s0166-0934(98)00039-1 QMRO: qmroHref Nelson JL, Furst DE, Maloney S et al. (1998). Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. nameOfConference DOI: 10.1016/s0140-6736(97)08357-8 QMRO: qmroHref DisclosuresNo disclosures. Back to top