Dr Daniel Harding

Profile

Dr Harding is a NHIR sponsored Clinical Lecturer in the Marelli-Berg laboratory at Queen Mary University of London (QMUL). He completed his chemistry and medical degrees at the University of Oxford prior to undertaking his clinical cardiology training in London. His research background includes molecular biology (Oxford, Prof C Schofield) and genetic immunology (London, Prof F Brennan). He was previously an Academic Clinical Fellow at University College London (UCL) before joining QMUL for his BHF funded PhD in cardioimmunology.

Research

Group members

Dr Harding is currently part of the Professor Marelli-Berg laboratory.

Summary

Our research focuses on the role of the immune system in inflammatory cardiovascular disease. We have a clinical interest in dilated cardiomyopathy (DCM), acute myocarditis and infective endocarditis. We are also exploring the immune response to cardiogenic shock. 

Key Publications

• Shyam-Sundar V, Harding D, Khan A, Abdulkareem M, Slabaugh G, Mohiddin SA, Petersen SE, Aung N ( 2024 ) . Imaging for the diagnosis of acute myocarditis: can artificial intelligence improve diagnostic performance? .Frontiers in Cardiovascular Medicine vol. 11,10.3389/fcvm.2024.1408574.
  https://qmro.qmul.ac.uk/xmlui/handle/123456789/98897
• Papadopoulou A, Harding D, Slabaugh G, Marouli E, Deloukas P ( 2024 ) . Prediction of atrial fibrillation and stroke using machine learning models in UK Biobank . Heliyon vol. 10 , ( 7 )
  10.1016/j.heliyon.2024.e28034
  https://qmro.qmul.ac.uk/xmlui/handle/123456789/95921
• Golino M, Harding D, Del Buono MG, Fanti S, Mohiddin S, Toldo S, Smyth J, Sanna T et al. ( 2024 ) . Innate and adaptive immunity in acute myocarditis . International Journal of Cardiology vol. 404 ,
  10.1016/j.ijcard.2024.131901
  https://qmro.qmul.ac.uk/xmlui/handle/123456789/96019
• Harding D, Fanti S, Marelli-Berg F ( 2023 ) . Tumour necrosis factor-α in cardiac inflammation: friend or foe? . Cardiovascular Research vol. 120 , ( 1 ) 1 - 2.
  10.1093/cvr/cvad180
  https://qmro.qmul.ac.uk/xmlui/handle/123456789/94929
• Harding D, Marelli-Berg F ( 2023 ) . Interferon-gamma signs off an old heart . Cardiovascular Research vol. 119 , ( 14 ) 2387 - 2389 .
  10.1093/cvr/cvad151
  https://qmro.qmul.ac.uk/xmlui/handle/123456789/91978
• Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS et al. ( 2022 ) . Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity . Circulation vol. 146 , ( 25 ) 1930 - 1945.
  10.1161/circulationaha.121.055610
  https://qmro.qmul.ac.uk/xmlui/handle/123456789/83023
• Harding D, Chong MHA, Lahoti N, Bigogno CM, Prema R, Mohiddin SA, Marelli‐Berg F ( 2022 ) . Dilated cardiomyopathy and chronic cardiac inflammation: Pathogenesis, diagnosis and therapy . Journal of Internal Medicine vol. 293 , ( 1 ) 23 - 47 .
  10.1111/joim.13556
  https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/80520
• Sotto I, Arefin R, Mouyis K, Toma T, Lee LY, Harding D, Perez C, Mohammad H et al. ( 2020 ) . 65 Changes in anticoagulant use in England over two decades: 1998-2018 . Heart vol. 106 , ( Suppl 2 ) a51 - a52 .
  10.1136/heartjnl-2020-bcs.65
• Hayward C, Mouyis K, Gillott H, Adasuriya G, Ng SM, Harvey G, Akhtar MA, Mohammad H et al. ( 2020 ) . 88 National confidential enquiry into patient outcome and death in patients admitted with heart failure: a quality improvement project to improve compliance with recommendations . Conference: Heart Failurea68 - a69 .
  10.1136/heartjnl-2020-bcs.88
• Harding D, Cahill TJ, Redwood SR, Prendergast BD ( 2020 ) . Infective endocarditis complicating transcatheter aortic valve implantation . Heart vol. 106 , ( 7 )
  10.1136/heartjnl-2019-315338
• Hayward C, Perez C, Patel H, Mouyis K, Patel K, Akhtar M, Harding D, Adasuriya G et al. ( 2019 ) . 11 The impact of misclassifying left ventricular size if indexing to body surface area is not performed . Heart . Conference: Imaging vol. 105 ,
  10.1136/heartjnl-2019-bcs.11
• Harding D, Prendergast B ( 2018 ) . Advanced imaging improves the diagnosis of infective endocarditis . F1000Research vol. 7 ,
  10.12688/f1000research.13791.1
• Nagendran M, Harding D, Teo W, Camm C, Maruthappu M, McCulloch P, Hopewell S ( 2013 ) . Poor adherence of randomised trials in surgery to CONSORT guidelines for non-pharmacological treatments (NPT): a cross-sectional study . BMJ Open vol. 3 , ( 12 )
  10.1136/bmjopen-2013-003898
• Hamed RB, Gomez-Castellanos JR, Thalhammer A, Harding D, Ducho C, Claridge TDW, Schofield CJ ( 2011 ) . Stereoselective C–C bond formation catalysed by engineered carboxymethylproline synthases . Nature Chemistry vol. 3 , ( 5 ) 365 - 371 .
  10.1038/nchem.1011

Collaborators

Internal
Professor Federica Marelli-Berg; Dr Suchita Nadkarni; Dr Paula Longhi; Dr Alastair Proudfoot; Dr Vijay Shyam-Sundar

External
Dr Barbara Szomolay (Cardiff)

Industry
Astrazeneca 

Teaching

Dr Harding supervises undergraduate students on the BIO604 and SSC4 programmes at QMUL. He also teaches clinical cardiology to undergraduate medical students at UCL and is a OSCE examiner for QMUL.

Disclosures

No disclosures.