Dr Dan Jones

Profile

Daniel Jones is a Reader based within Barts Cardiovascular Clinical Trials Unit (CVCTU) and an Interventional Cardiologist at Barts Heart Centre. He completed his medical degree (MBBS) at St Georges Hospital Medical School in 2004, which involved an Intercalated BSc (2:1) in basic medical science awarded in 2001. He completed his PhD funded through an NIHR Doctoral Research Fellowship in 2015 at Queen Mary University of London based on the Investigation of the effect of nitrite in the management and treatment of myocardial infarction’ performed with Professors Anthony Mathur and Amrita Ahluwalia.

His primary research interests are based around translational interventional clinical trials, having completing an MSc in clinical trial design. Other interests include the treatment of reperfusion injury following myocardial infarction, novel therapies for myocardial regeneration, the cost-effectiveness of cardiovascular therapies and the study of outcomes after percutaneous coronary intervention.

Awards

• 2023 SCCT Clinical Trials and Registry Award: BYPASS-CTCA Sub-study
• 2022 HSJ Award Acute Sector Intervention: Barts AMI Discharge Pathway
• 2021  BMJ Award: Stroke and Cardiovascular Team of The Year: “Barts Early Discharge after AMI”
• 2019 Young Leadership Award – CRT 2019
• 2017 Young Investigator Award ‘Outcome after PCI’ at the ESC Annual Congress, Barcelona
  2017 Award for Academic Achievement 150th Anniversary Prize Awarded by  University of London
• 2015 Young Investigator Award 6th International Meeting on the Role of Nitrite and Nitrate in Physiology, Pathophysiology, and Therapeutics

Research

Group members

Barts Interventional Cardiology Research Department: Prof Anthony Mathur, Prof Andreas Baumbach, Mervyn Andiapen, Ruth Bowles, Lucinda Wynne

Vascular Pharmacology Group: Prof Amrita Ahluwalia (Head), Vikas Kapil (Senior Lecturer), Dr Krishnaraj Rathod (Senior Lecturer)

Barts Cardiovascular CTU: Prof Amrita Ahluwalia (Director), Ms Jessica Adams, (Manager), Dr Ajay Gupta (Senior Lecturer)

Summary 

Dr Jones's research focus is around improving outcomes for patients with coronary artery disease specifically those undergoing invasive coronary procedures. There is a strong focus on translational cardiovascular research, with his main interest being taking the potential benefits of nitric oxide from bench to bedside in the treatment of cardiovascular disease and the use of CTCA in improving outcomes in the post-bypass patient. 

Inorganic Nitrite/Nitrate in Cardiovascular Disease: A major research focus is the use of inorganic nitrate/nitrite and cardiovascular outcomes. In 2015 as part of his PhD he helped demonstrate that intracoronary nitrite reduces infarct size and improve outcomes after primary angioplasty for myocardial infarction in a first in man phase II study.  
On-going research focuses on Inorganic nitrate for prevention of contrast nephropathy after percutaneous coronary intervention (PCI) - https://heartresearch.org.uk/grants/coronary-angiography 

CT Coronary Angiography for improving outcomes in patients post CABG: Dr Jones was the PI of the recently completed BYPASS-CTCA study assessing the routine use of upfront CTCA prior to invasive angiography to improve procedural metrics, outcomes and patient satisfaction. This was presented at TCT in 2022 and published in Circulation, and the subject of an award from SCCT in 2023. 

Clinical Trials: Focus of clinical trials in interventional cardiology alongside Prof Anthony Mathur and Prof Andreas Baumbach

Current areas include:

• Stem Cell Therapy for treatment of Heart Failure/Refractory Angina
• Improving revascularisation in the post-surgical patient
• Optimisation of Outcomes post MI (DAPA-MI, LIBREXIA-ACS, COMPLETE-2_
• Risk-stratification in MI with normal coronary arteries (MINOCA)

Key Publications

Full list of publications

1. Antoniou S, Colicchia M, Guttmann O, Rathod K, Wright P, Fhadil S, Knight C, Jain AK, Smith EJ, Mathur A, Weerackody R, Wragg A, Jones DA. Risk Scoring to guide anti-platelet therapy post percutaneous coronary intervention (PCI) for acute-coronary syndrome (ACS) results in improved clinical outcomes. Eur Heart J Qual Care Clin Outcomes. 2017 Nov 8. doi: 10.1093/ehjqcco/qcx041
2. Choudhury T, Choudhury F, Mozid A, Hamshere S, Yeo C, Pellaton C, Arnous S, Saunders N, Brookman P, Jain A, Locca D, Archbold RA, Knight CJ, Wragg A, Davies LC, Mills PG, Parmar M, Rothman MT, Jones DA, Agrawal S, Martin J, Mathur A. An exploratory randomised control study of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with ischaemic cardiomyopathy: the REGENERATE-IHD clinical trial. European Journal of Heart Failure 2017; 19(1):138-47
3. Jones DA, Khambata RS, Rathod KS, Andiapen M, Mathur A, Ahluwalia A. Intra-coronary nitrite suppresses the inflammatory response following primary percutaneous coronary intervention. Heart 2017;103(7):508-516.
4. Choudry F, Hamshere S, Saunders N, Veerapen J, Bavnbek K, Knight C, Pellerin D, Locca D, Westwood M, Rakhit R, Crake T, Kastrup J, Parmar M, Agrawal S, Jones D, Martin J, Mathur A. A randomized double-blind control study of early intra-coronary  autologous bone marrow cell infusion in acute myocardial infarction: the REGENERATE-AMI clinical trial. Eur Heart J. 2016;37:256-263.
5. Hamshere, S, Arnous S, Choudhury T, Choudry F, Mozid A, Yeo C, Barrett C, Saunders N, Gulati A, Knight C, Locca D, Davies C, Cowie MR, Prasad S, Parmar M, Agrawal S, Jones D, Martin J, McKenna W, Mathur A. Randomized trial of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with non-ischaemic dilated cardiomyopathy: the REGENERATE-DCM clinical trial. Eur Heart J 2015;36(44):3061-9 
6. Jones DA, Rathod KS, Gallagher S, Jain AK, Kalra SS, Lim P, Crake T, Ozkor M, Rakhit R, Knight CJ, Iqbal MB, Dalby MC, Malik IS, Whitbread M, Mathur A1, Redwood S, MacCarthy PA, Weerackody R, Wragg A. Manual Thrombus aspiration is not associated with reduced mortality in Patients Treated with Primary Percutaneous Coronary Intervention: An Observational Study of 10,929 patients with ST-Elevation Myocardial Infarction from the London Heart Attack Group. JACC Cardiovasc Interv. 2015 Apr 20;8(4):575-84. doi: 10.1016/j.jcin.2014.11.021. 
7. Jones DA, Pellaton C, Velmurugan S, Rathod KS, Andiapen M, Antoniou S, van Eijl S, Webb AJ, Westwood MJ, Parmar MK, Mathur A, Ahluwalia A. 2015. Randomized phase 2 trial of intracoronary nitrite during acute myocardial infarction. Circ Res 2015; 116: 437-447.
8. Jones DA, Gallagher S, Rathod K, Jain AK, Mathur A, Uppal R, Westwood M, Wong K, Rothman MT, Shipolini A, Smith EJ, Mills PG, Timmis AD, Knight CJ, Archbold RA, Wragg A. Clinical outcomes after myocardial revascularization according to operator training status: cohort study of 22 697 patients undergoing percutaneous coronary intervention or coronary artery bypass graft surgery. Eur Heart J. 2013 2013;34(37):2887-95

Collaborators

Internal
Dr Andrew Wragg; Dr Malcolm Finlay

External 
Prof Colin Berry; Prof Vijay Kunadian; Dr Thomas Keeble

News

• Dietary Nitrate Dramatically Cuts Contrast-Induced Nephropathy (tctmd), August 2023
• Inorganic nitrate improves safety of coronary angiography in patients at renal injury risk (European Society of Cardiology), August 2023
• CCTA in Patients With Prior CABG Cuts Complications of Invasive Angio: BYPASS-CTCA (tctmd), September 2022

Teaching

Dr Jones has a strong commitment to teaching and training within the university. He is involved in teaching medical students on the MBBS course and PA students on the Physician Associate MSc course. He also regularly mentors students for SSC1 and SSC4 on the QMUL undergraduate syllabus and supervisors QMUL medical students for summer elective modules (Rod Flower Scholarship (per year last 3 years). 

MD/PhD Supervision: To date, Dr Jones has supervised 1 student to the completion of a PhD as 2nd supervisor and is currently the primary supervisor for 3 ongoing PhD/MD students. 

He also runs the Cardiology Boot Camp for Physician Associates and Allied Health Professionals through QMUL and the CVDHub and contributes to regular short courses and teaching through the CVDHub. 

Disclosures

No disclosures.