Professor Ahuva NissimProfessor in Antibody and Therapeutic Engineering Centre: Biochemical PharmacologyEmail: a.nissim@qmul.ac.ukTelephone: +44(0) 20 7882 3990ProfileResearchPublicationsSponsorsCollaboratorsProfile Ahuva Nissim graduated in Molecular Immunology in 1992 from the Weizmann Institute of Science in Israel and was trained as a postdoctoral fellow at the MRC Centre for Protein Engineering in Cambridge until 1995. During this period she developed phage display semi-synthetic human antibody library, the so call ‘Nissim’ library which has been used worldwide. In November 2000 she was appointed as a Senior Lecturer at Queen Mary University of London. Her studies are interdisciplinary and involve translational research at the William Harvey Research Institute and with intensive worldwide collaborations. Her studies have been mostly focused on the mechanisms that lead to the formation of disease tissue-specific pathogenic proteins and the exploitation of identified pathogenic proteins to develop platform technologies for novel disease - and tissue-specific, diagnosis and targeted treatment. ResearchGroup members MD/PhD research fellows: Dr Rocky Strollo (with Prof Pozzilli as part of international collaboration with Campus Bio-Medico University of Rome) Students: Chiara Vinci (with Prof Pozzilli), Louise Mary Topping (with Helena Azevedo); Anastasija Pikus (with Prof Leslie) Research staff: Dr Michael Tranter; Dr Sagar Raturi, Dr Stella Man Summary The main research interest focuses on development of diseased tissue specific diagnosis and targeted immunotherapy to novel neoantigens produced specifically in diseased tissue. The role of oxidants in generation of neoantigen in the diseased tissues as a results of oxidative post-translational modification is investigated. Research is focused on arthropathies and type 1 diabetes but other autoimmune condition such as periodontal diseases have been studied. Hence, a specific targeted immunotherapy for the treatment of arthropathies has been developed. Ongoing research activities include the development of novel human antibody repertoires for engineering of new treatment modalities. Publications Esposito I, Kontra I, Giacomassi C et al. (publicationYear). Identification of autoantigens and their potential post-translational modification in EGPA and severe eosinophilic asthma. nameOfConference DOI: 10.3389/fimmu.2023.1164941 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/88872 Strollo R, Vinci C, Man YKS et al. (2023). Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes. nameOfConference DOI: 10.1007/s00125-022-05812-4 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92331 Gigout A, Harazin D, Topping LM et al. (2021). Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species. nameOfConference DOI: 10.1186/s13075-021-02502-1 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92332 Vinci C, Infantino M, Raturi S et al. (2020). Immunoglobulin A antibodies to oxidized collagen type II as a potential biomarker for the stratification of spondyloarthritis from rheumatoid arthritis. nameOfConference DOI: 10.1080/03009742.2020.1713395 QMRO: qmroHref Topping LM, Thomas BL, Rhys HI et al. (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. nameOfConference DOI: 10.3389/fimmu.2020.00010 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63161 Nissim A (2019). 016 Targeting combined treatment to arthritic joints by antibody specific to damaged cartilage. nameOfConference DOI: 10.1093/rheumatology/kez106.015 QMRO: qmroHref Strollo R, Vinci C, Napoli N et al. (2019). Antibodies to oxidized insulin improve prediction of type 1 diabetes in children with positive standard islet autoantibodies. nameOfConference DOI: 10.1002/dmrr.3132 QMRO: qmroHref Nissim A (2019). TARGETING COMBINED TREATMENT TO ARTHRITIC JOINTS BY ANTIBODY SPECIFIC TO DAMAGED CARTILAGE. nameOfConference DOI: doi QMRO: qmroHref Topping LM, Vinci C, Rhys H et al. (2018). OP0260 Targeting neutrophil microvesicles to damaged cartilage using antibodies to post-translationally modified collagen ii. FRIDAY, 15 JUNE 2018 DOI: 10.1136/annrheumdis-2018-eular.6744 QMRO: qmroHref Smallwood MJ, Nissim A, Knight AR et al. (2018). Oxidative stress in autoimmune rheumatic diseases. nameOfConference DOI: 10.1016/j.freeradbiomed.2018.05.086 QMRO: qmroHref Strollo R, Vinci C, Napoli N et al. (2018). Antibodies to oxidised insulin improve prediction of type 1 diabetes in children with positive standard islet-autoantibodies. nameOfConference DOI: doi QMRO: qmroHref Topping L, Rhys H, Norling L et al. (2017). FRI0011 Targeting neutrophil microvesicles to damaged cartilage using antibodies to post translationally modified collagen ii. Poster Presentations DOI: 10.1136/annrheumdis-2017-eular.4842 QMRO: qmroHref Vinci C, Infantino M, Pozzilli P et al. (2017). FRI0423 Antibodies to type ii collagen: a novel tool for the spondyloarthritis diagnosis?. Poster Presentations DOI: 10.1136/annrheumdis-2017-eular.3498 QMRO: qmroHref Strollo R, Vinci C, Napoli N et al. (2017). Antibodies to post-translationally modified insulin as a novel biomarker for prediction of type 1 diabetes in children. nameOfConference DOI: 10.1007/s00125-017-4296-1 QMRO: qmroHref Nissim A, Hughes C, Faurholm B et al. (2017). 06.09 Targeting therapeutic and regenerative biomedicine specifically to arthritic joints. Novel technologies DOI: 10.1136/annrheumdis-2016-211053.9 QMRO: qmroHref Strollo R, Vinci C, Napoli N et al. (2017). Antibodies to Posttranslationally Modified Insulin for Prediction of Type 1 Diabetes in Children. nameOfConference DOI: doi QMRO: qmroHref Rizzo P, Pitocco D, Zaccardi F et al. (2017). Autoantibodies to post‐translationally modified type I and II collagen in Charcot neuroarthropathy in subjects with type 2 diabetes mellitus. nameOfConference DOI: 10.1002/dmrr.2839 QMRO: qmroHref Hughes C, Nissim A (2016). Progress and clinical potential of antibody-targeted therapy for arthritic damage. nameOfConference DOI: 10.1080/14789450.2016.1188008 QMRO: qmroHref Nissim A (publicationYear). COMBINATORIAL ANTIBODY PHAGE DISPLAY LIBRARIES CONSTRUCTED FROM B-CELLS INFILTRATING BRAIN TISSUE OF PEOPLE WITH PROGRESSIVE MULTIPLE SCLEROSIS. nameOfConference DOI: 10.26226/morressier.56e174d9d462b8028d88acbe QMRO: qmroHref Lim NH, Vincent TL, Nissim A (2016). Detection of early osteoarthritis by in vivo optical imaging of an antibody specific to type II collagen damaged by reactive oxidants. nameOfConference DOI: 10.1016/j.joca.2016.01.121 QMRO: qmroHref Lim NH, Vincent TL, Nissim A (2015). In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage. nameOfConference DOI: 10.1186/s13075-015-0898-5 QMRO: qmroHref Strollo R, Vinci C, Arshad MH et al. (2015). Antibodies to post-translationally modified insulin in type 1 diabetes. nameOfConference DOI: 10.1007/s00125-015-3746-x QMRO: qmroHref (2015). Cohen-Saidon C, Nechushtan H, Kahlon S, Livni N, Nissim A, Razin E. A novel strategy using single-chain antibody to show the importance of Bcl-2 in mast cell survival. Blood. 2003;102(7):2506-2512.. nameOfConference DOI: 10.1182/blood-2015-02-631499 QMRO: qmroHref Kuhle J, Gaiottino J, Leppert D et al. (2015). Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome.. nameOfConference DOI: 10.1136/jnnp-2013-307454 QMRO: qmroHref Strollo R, Vinci C, Arshad MH et al. (2015). Autoantibodies to posttranslationally modified insulin in type 1 diabetes. nameOfConference DOI: doi QMRO: qmroHref Hughes C, Sette A, Seed M et al. (2014). Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency.. nameOfConference DOI: 10.1186/ar4613 QMRO: qmroHref Burska AN, Hunt L, Boissinot M et al. (2014). Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis. nameOfConference DOI: 10.1155/2014/492873 QMRO: qmroHref Ryan BJ, Nissim A, Winyard PG (2014). Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases.. nameOfConference DOI: 10.1016/j.redox.2014.05.004 QMRO: qmroHref Kuhle J, Plattner K, Bestwick JP et al. (2013). A comparative study of CSF neurofilament light and heavy chain protein in MS.. nameOfConference DOI: 10.1177/1352458513482374 QMRO: qmroHref Puentes F, Topping J, Kuhle J et al. (2014). Immune reactivity to neurofilament proteins in the clinical staging of amyotrophic lateral sclerosis. nameOfConference DOI: 10.1136/jnnp-2013-305494 QMRO: qmroHref Strollo R, Ponchel F, Malmström V et al. (2013). Autoantibodies to posttranslationally modified type II collagen as potential biomarkers for rheumatoid arthritis.. nameOfConference DOI: 10.1002/art.37964 QMRO: qmroHref Eggleton P, Nissim A, Ryan BJ et al. (2013). Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens.. nameOfConference DOI: 10.1016/j.freeradbiomed.2012.11.006 QMRO: qmroHref Strollo R, Rizzo P, Spoletini M et al. (2013). HLA-dependent autoantibodies against post-translationally modified collagen type II in type 1 diabetes mellitus.. nameOfConference DOI: 10.1007/s00125-012-2780-1 QMRO: qmroHref Maggiore C, Giovannoni G, Martin J et al. (2013). Construction of an antibody phage display library from B-cells infiltrating brain tissue of people with progressive multiple sclerosis. nameOfConference DOI: doi QMRO: qmroHref Gaiottino J, Norgren N, Dobson R et al. (2013). Increased neurofilament light chain blood levels in neurodegenerative neurological diseases.. nameOfConference DOI: 10.1371/journal.pone.0075091 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/54859 Man YKS, DiCara D, Chan N et al. (2013). Structural guided scaffold phage display libraries as a source of bio-therapeutics.. nameOfConference DOI: 10.1371/journal.pone.0070452 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74180 Wythe SE, DiCara D, Taher TEI et al. (2013). Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide.. nameOfConference DOI: 10.1136/annrheumdis-2012-201457 QMRO: qmroHref Rizzo P, Pitocco D, Scavone G et al. (2013). The Role of Collagen Neoepitopes Generated by Oxidative Stress in the Pathogenesis of Charcot Neuroarthropathy. nameOfConference DOI: doi QMRO: qmroHref Winyard⁎ PG, Nissim A, Ryan B et al. (2012). Measurement of serum autoantibodies against oxidatively modified autoantigens in human autoimmune diseases. nameOfConference DOI: 10.1016/j.freeradbiomed.2012.08.555 QMRO: qmroHref Harel D, Marron A, Nissim A et al. (2012). A Software Engineering Framework for Switched Fuzzy Systems. 2012 IEEE International Conference on Fuzzy Systems DOI: 10.1109/fuzz-ieee.2012.6251301 QMRO: qmroHref Hughes C, Faurholm B, Dell'Accio F et al. (2012). TARGETING THERAPEUTICS TO ARTHRITIC JOINTS BY ANTIBODY SPECIFIC TO POST-TRANSLATIONALLY MODIFIED COLLAGEN TYPE II. nameOfConference DOI: 10.1136/annrheumdis-2011-201230.16 QMRO: qmroHref Kamperidis P, Kamalati T, Ferrari M et al. (2011). Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis.. nameOfConference DOI: 10.1002/art.30650 QMRO: qmroHref Winyard PG, Ryan B, Eggleton P et al. (2011). Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease.. nameOfConference DOI: 10.1042/BST0391226 QMRO: qmroHref Hughes C, Faurholm B, Dell'Accio F et al. (2011). TARGETING THERAPEUTICS TO ARTHRITIC JOINTS. nameOfConference DOI: doi QMRO: qmroHref Kamperidis P, Kamalati T, Ferrari M et al. (2011). Development of a Novel Recombinant Biotherapeutic with Applications in Targeted Therapy of Human Arthritis.. nameOfConference DOI: doi QMRO: qmroHref Anger J, Rogo-Gupta L, Behniwal A et al. (2011). IS "OAB-DRY" REALLY DRY?. nameOfConference DOI: doi QMRO: qmroHref Eggleton P, Ryan B, Brown S et al. (2011). POST-TRANSLATIONAL MODIFICATIONS OF C1Q LEAD TO ANTIGENICITY AND BREAKDOWN OF IMMUNE TOLERANCE IN SYSTEMIC LUPUS ERYTHEMATOSUS. nameOfConference DOI: doi QMRO: qmroHref Hughes C, Faurholm B, Dell'Accio F et al. (2011). Targeting therapeutics to arthritic joints. nameOfConference DOI: doi QMRO: qmroHref Nissim A, DiCara D (2010). Methods for Development of Monoclonal Antibody Therapeutics. nameOfConference DOI: doi QMRO: qmroHref Hendler A, Mulli TK, Hughes FJ et al. (2010). Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis. nameOfConference DOI: 10.1177/0022034510381903 QMRO: qmroHref Hughes C, Faurholm B, Dell'Accio F et al. (2010). Human single-chain variable fragment that specifically targets arthritic cartilage.. nameOfConference DOI: 10.1002/art.27346 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19241 Wythe SE, DiCara D, Finucane C et al. (2010). TARGETING THE INFLAMED MICROVASCULATURE IN RHEUMATOID ARTHRITIS. nameOfConference DOI: doi QMRO: qmroHref Ryan B, Eggleton P, Brown S et al. (2010). Oxidative and Nitrative Modification of C1q Affects its Structure, Function and Antigenicity in Systemic Lupus Erythematosus. nameOfConference DOI: 10.1016/j.freeradbiomed.2010.10.415 QMRO: qmroHref Ryan B, Winyard PG, Viner N et al. (2009). OXIDATIVE MODIFICATIONS TO C1Q INCREASE THE SENSITIVITY OF AN ANTI-C1Q ELISA IN THE DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS. nameOfConference DOI: doi QMRO: qmroHref Maggiore C, Meier UC, Marta M et al. (2009). B Cells and EBV Infection in People with MS. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/7010 Nissim A, Chernajovsky Y (2008). Preface. nameOfConference DOI: doi QMRO: qmroHref Maggiore C, Trillo-Pazos G, Keir G et al. (2008). Ectopic germinal centres in the brain of people with multiple sclerosis. nameOfConference DOI: doi QMRO: qmroHref Nissim A, Chernajovsky Y (2008). Historical development of monoclonal antibody therapeutics.. nameOfConference DOI: 10.1007/978-3-540-73259-4_1 QMRO: qmroHref Nissim A (2008). NOVEL ANTIBODY AND USE IN DIAGNOSIS AND THERAPY OF ARTHROPATHIES. nameOfConference DOI: doi QMRO: qmroHref Ryan B, Szestakowska D, Viner N et al. (2007). Autoantibodies target oxidatively modified proteins of the C1q/calreticulin/CD91 apoptotic pathway in systemic lupus erythematosus. nameOfConference DOI: doi QMRO: qmroHref Brunton F, Lee L, Nissim A et al. (2007). Targeting osteoclasts in rheumatoid arthritis via the alpha(v)beta(3) integrin. nameOfConference DOI: doi QMRO: qmroHref Kamperidis PS, Lee L, Blades M et al. (2007). Identification of single-chain antibody fragments specific for human synovial microvascular endothelium by in vivo phage display. nameOfConference DOI: doi QMRO: qmroHref Brunton F, Lee L, Nissim A et al. (2007). Modulating osteoclast function by targeting the alphavbeta3 integrin. nameOfConference DOI: doi QMRO: qmroHref Nissim A, Chernajovsky Y (2007). Therapeutic Antibodies. nameOfConference DOI: doi QMRO: qmroHref Eggleton P, Szestakowska D, Winyard PG et al. (2006). Generation of neo-antigenic epitopes recognised by autoimmune sera after the post-translational modification of human C1q by free radicals. nameOfConference DOI: doi QMRO: qmroHref Winyard PG, Nissim A, Davies C et al. (2006). Nitrosative stress in the inflamed joints of rheumatoid arthritis patients. nameOfConference DOI: doi QMRO: qmroHref Szestakowska D, Young P, Morse R et al. (2006). Role of oxidative protein modifications in the generation of neoantigens recognised by lupus patient sera. nameOfConference DOI: doi QMRO: qmroHref Chernajovsky Y, NISSIM A, Perrett D et al. (2005). Generation of neoantigenic epitopes after posttranslational modification of type II collagen by factors present within the inflamed joint. nameOfConference DOI: 10.1002/art.21479 QMRO: qmroHref Nissim A, Winyard PG, Corrigall V et al. (2005). Generation of neoantigenic epitopes after posttranslational modification of type II collagen by factors present within the inflamed joint.. nameOfConference DOI: 10.1002/art.21479 QMRO: qmroHref Yudkoff M, Daikhin Y, Nissim A et al. (2005). Brain amino acid requirements and toxicity: The example of leucine (vol 135, pg 1531S, 2005). nameOfConference DOI: doi QMRO: qmroHref Horyn O, Luhovyy B, Lazarow A et al. (2005). Biosynthesis of agmatine in isolated mitochondria and perfused rat liver: studies with N-15-labelled arginine. nameOfConference DOI: 10.1042/BJ20041260 QMRO: qmroHref Nissim A, Winyard P, Davis C et al. (2005). Development of human antibody fragments against collagen type II autoantigens in rheumatoid arthritis, using phage display libraries. nameOfConference DOI: doi QMRO: qmroHref Inglis JJ, Nissim A, Lees DM et al. (2005). The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation.. nameOfConference DOI: 10.1186/ar1743 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18144 Nissim A, Winyard P, Fatah R et al. (2004). Generation of neo-antigenic epitopes after the post-translational modification of type II collagen by factors present within the inflamed joint.. nameOfConference DOI: doi QMRO: qmroHref Nissim A, Gofur Y, Vessillier S et al. (2004). Methods for targeting biologicals to specific disease sites.. nameOfConference DOI: 10.1016/j.molmed.2004.04.003 QMRO: qmroHref NISSIM A, Nechushtan H, Cohen-Saidon C et al. (2003). A novel strategy using single chain antibody to show the importance of Bcl-2 in mast cell survival.. nameOfConference DOI: 10.1182/blood-2002-12-3921 QMRO: qmroHref NISSIM A, Loyter A, Piller SC et al. (2003). Antibody Fragments Selected by Phage Display Against the Nuclear Localization Signal of the HIV-1 Vpr Protein Inhibit Nuclear Import in Permeabilized and Intact Cultured Cells.. nameOfConference DOI: 10.1006/viro.2002.1765 QMRO: qmroHref Yagil E, Beacham IR, Nissim A et al. (1978). Crypticity of periplasmic enzymes Involvement of protein b in the permeability of the outer membrane of Escherichia coli. nameOfConference DOI: 10.1016/0014-5793(78)81264-2 QMRO: qmroHref Gargir A, Ofek I, Meron-Sudai S et al. (2002). Single chain antibodies specific for fatty acids derived from a semi-synthetic phage display library. nameOfConference DOI: 10.1016/s0304-4165(01)00245-8 QMRO: qmroHref Flores-Flores C, Nissim A, Shochat S et al. (2002). Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library. nameOfConference DOI: doi QMRO: qmroHref NISSIM A, Soreq H, Flores-Flores C et al. (2002). Phage display selection and characterization of myc-tagged humanized monoclonal antibodies to synaptic acetylcholinesterase.. nameOfConference DOI: doi QMRO: qmroHref Gargir A, Ofek I, Hasty D et al. (2001). Inhibition of anti body-dependent stimulation of lipoteichoic acid-treated human monocytes and macrophages by polyglycerolphosphate-reactive peptides. nameOfConference DOI: 10.1189/jlb.70.4.537 QMRO: qmroHref Kjaer S, Wind T, Ravn P et al. (2001). Generation and epitope mapping of high-affinity scFv to eukaryotic elongation factor 1A by dual application of phage display. nameOfConference DOI: 10.1046/j.1432-1327.2001.02240.x QMRO: qmroHref Vaisman N, Nissim A, Klapper LN et al. (2000). Specific inhibition of the reaction between a tumor-inhibitory antibody and the ErbB-2 receptor by a mimotope derived from a phage display library.. nameOfConference DOI: 10.1016/s0165-2478(00)00278-9 QMRO: qmroHref Uchanska-Ziegler B, Xugang Q, Volz A et al. (2000). Human Single-Chain Fv Fragments Specific for Natural Killer Cell Receptors from Phage Display Libraries. nameOfConference DOI: 10.1385/1-59259-044-6:219 QMRO: qmroHref Uchanska-Ziegler B, Qiao X, Volz A et al. (2000). Human single-chain Fv fragments specific for natural killer cell receptors from phage display libraries.. nameOfConference DOI: 10.1385/1-59259-044-6:219 QMRO: qmroHref Neri D, Pini A, Nissim A (publicationYear). Antibodies from Phage Display Libraries as lmmunochemical Reagents. nameOfConference DOI: 10.1385/0-89603-493-3:475 QMRO: qmroHref Neri D, Pini A, Nissim A (1998). Antibodies from phage display libraries as immunochemical reagents.. nameOfConference DOI: 10.1007/978-1-59259-257-9_47 QMRO: qmroHref Neri D, Carnemolla B, Nissim A et al. (1997). Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform. nameOfConference DOI: 10.1038/nbt1197-1271 QMRO: qmroHref Neri D, Carnemolla B, Nissim A et al. (1997). Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform.. nameOfConference DOI: 10.1038/nbt1197-1271 QMRO: qmroHref Evenor D, Levi-Nissim A, Afgin L et al. (1997). Regeneration of plantlets and bulblets from explants and callus of Allium aflatunense cultivars and selection from indigenous Israeli Allium ampeloprasum. nameOfConference DOI: 10.17660/ActaHortic.1997.430.50 QMRO: qmroHref Oren-Shamir M, Levi-Nissim A (1997). UV-light effect on the leaf pigmentation of Cotinus coggygria 'Royal Purple'. nameOfConference DOI: 10.1016/S0304-4238(97)00073-3 QMRO: qmroHref Nissim A, Neri D, Winter G (1996). Development and usage of semi-synthetic scFv repertoires displayed on phage. nameOfConference DOI: doi QMRO: qmroHref Harrison JL, Williams SC, Winter G et al. (1996). Screening of phage antibody libraries.. nameOfConference DOI: 10.1016/s0076-6879(96)67007-4 QMRO: qmroHref Nissim A, Schwarzbaum S, Eshhar Z (1995). The Use of Mouse/Human IgE Chimeras to Map the FcϵR Binding Site of IgE. nameOfConference DOI: 10.1006/meth.1995.9994 QMRO: qmroHref GRIFFITHS AD, WILLIAMS SC, HARTLEY O et al. (1994). ISOLATION OF HIGH-AFFINITY HUMAN-ANTIBODIES DIRECTLY FROM LARGE SYNTHETIC REPERTOIRES. nameOfConference DOI: 10.1002/j.1460-2075.1994.tb06626.x QMRO: qmroHref Nissim A, Hoogenboom HR, Tomlinson IM et al. (1994). Antibody fragments from a 'single pot' phage display library as immunochemical reagents.. nameOfConference DOI: 10.1002/j.1460-2075.1994.tb06308.x QMRO: qmroHref NISSIM A, HOOGENBOOM HR, TOMLINSON IM et al. (1994). ANTIBODY FRAGMENTS FROM A SINGLE POT PHAGE DISPLAY LIBRARY AS IMMUNOCHEMICAL REAGENTS. nameOfConference DOI: doi QMRO: qmroHref Nissim A, Schwarzbaum S, Siraganian R et al. (1993). Fine specificity of the IgE interaction with the low and high affinity Fc receptor.. nameOfConference DOI: 10.4049/jimmunol.150.4.1365 QMRO: qmroHref Nissim A, Eshhar Z (1992). The human mast cell receptor binding site maps to the third constant domain of immunoglobulin E.. nameOfConference DOI: 10.1016/0161-5890(92)90038-y QMRO: qmroHref Rutherford MN, Kumar A, Nissim A et al. (1991). The murine 2-5A synthetase locus: three distinct transcripts from two linked genes.. nameOfConference DOI: 10.1093/nar/19.8.1917 QMRO: qmroHref NISSIM A, ESHHAR Z (1991). THE MAST-CELL BINDING-SITE MAPPS TO THE 3RD CONSTANT REGION DOMAIN OF IMMUNOGLOBULIN-E. nameOfConference DOI: doi QMRO: qmroHref Nissim A, Eshhar Z (1991). Localization of the Fc epsilon RI binding site to the third constant domain of IgE.. nameOfConference DOI: 10.1159/000235335 QMRO: qmroHref Nissim A, Jouvin MH, Eshhar Z (1991). Mapping of the high affinity Fc epsilon receptor binding site to the third constant region domain of IgE.. nameOfConference DOI: 10.1002/j.1460-2075.1991.tb07925.x QMRO: qmroHref Coccia EM, Romeo G, Nissim A et al. (1990). A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication.. nameOfConference DOI: 10.1016/0042-6822(90)90292-y QMRO: qmroHref Schwarzbaum S, Nissim A, Alkalay I et al. (1989). Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions.. nameOfConference DOI: 10.1002/eji.1830190610 QMRO: qmroHref David S, Nissim A, Chebath J et al. (1989). 2'-5'-oligoadenylate synthetase gene expression in normal and murine sarcoma virus-transformed NIH 3T3 cells.. nameOfConference DOI: 10.1128/JVI.63.3.1116-1122.1989 QMRO: qmroHref NISSIM A, COCCIA E, COHEN B et al. (1987). 3 DIFFERENT 2'-5'OLIGO A SYNTHETASE GENES ARE ACTIVE IN MOUSE CELLS AND MULTIPLE FORMS OF ENZYMES ARE INDUCED BY INTERFERONS. nameOfConference DOI: doi QMRO: qmroHref CHITAYAT SD, NISSIM A, COCCIA C et al. (1987). 2-5A SYNTHETASE GENE-EXPRESSION IN NORMAL AND MSV-TRANSFORMED NIH/3T3 CELLS. nameOfConference DOI: doi QMRO: qmroHref Sponsors Versus Arthritis (Formerly Arthritis UK) Medical Research Council JDRF Collaborators Internal Costantinos Pitzalis (WHRI) Michele Bombardieri (WHRI) Francesco Dell'Accio (WHRI) Gavin Giovannoni (Blizard) David Lesly (Blizard) John Marshal (BCI) Helena Azevedo (School of Engineering) James Garnett (School of Biological and Chemical Sciences) Roberto Buccafusca (School of Biological and Chemical Sciences) External Paul G Winyard (Exeter) Pozzilli Paolo (Rome) Iain B McInnes, Carl S Goodyear (Glasgow) Frederique Ponchel, Philip G Conaghan, Paul Emery (Leeds) Tonia Vincent (Kennedy) Maria Infantino and Maurizio Benucci (Florence) Howard Amital (Israel) Zelig Eshhar (Israel) Industrial collaborators from Europe, Israel and US Back to top