Professor Peter MacCallum

Profile

I am a clinical academic at the Wolfson Institute of Population Health, Queen Mary University of London, and an honorary consultant haematologist at Barts Health NHS Trust where I lead the clinical and laboratory thrombosis service at St Bartholomew’s and the Royal London Hospitals.

My research interests cover the field of venous thromboembolism (VTE) and mirror my clinical practice.

Much clinical and research time since March 2020 has been taken up with firstly the thrombotic complications of COVID-19 and subsequently the diagnosis and management of vaccine-induced thrombosis with thrombocytopenia.

Over the past 5 years I have been Chief Investigator of the ORANGE study, a prospective UK-based registry of outcomes of major bleeding on oral anticoagulants and the largest such study globally, and National Co-ordinating Investigator for GARFIELD-VTE, a prospective global registry that studied the management and outcomes of >10,000 patients with a new episode of VTE from >30 countries and to which the UK was the largest contributor (>900 patients).

Future plans include a collaboration to better understand the pathways of coagulation activation in patients with cancer, who contribute 10-20% of the population burden of VTE and for whom thrombosis is a leading cause of death.

I have additionally authored chapters on thrombosis in major UK textbooks including the Oxford Textbook of Medicine, Kumar and Clark’s Clinical Medicine, and Postgraduate Haematology. 

I regularly teach medical students in PBLs and tutorials and some of my students have gone on to present findings from their specialist study modules at national and international conferences. I also act as student mentor. Despite the problems resulting from the COVID-19 pandemic my current MD(Res) student passed her viva within 4 years.

Research

Research Interests:

Thrombosis – epidemiology; pathogenesis of cancer-associated thrombosis; diagnosis, prevention and management of venous thromboembolism; personalised medicine approach to VTE management

Publications

Green L, Tan J, Morris JK, Alikhan R, Curry N, Everington T, Maclean R, Saja K, Stanworth S, Tait C, MacCallum P. A three-year prospective study of the presentation and clinical outcomes of major bleeding episodes associated with oral anticoagulant use in the UK (ORANGE study). Haematologica 2018;103:738-45. doi: 10.3324/haematol.2017.182220.

Young AM, Marshall A, Thirlwall J, Chapman O, Lokare A, Hill C, Hale D, Dunn JA, Lyman GH, Hutchinson C, MacCallum P, Kakkar A, Hobbs R, Petrou S, Dale J, Poole CJ, Levine M. Comparison of an oral factor Xa inhibitor with low molecular weight heparin in cancer patients with venous thromboembolism: results of a randomized trial (SELECT-D). J Clin Oncol 2018;36:2017-23. doi: 10.1200/JCO.2018.78.8034. 

Bowles L, Platton S, Yartey N, Dave M, Lee K, Hart DP, MacDonald V, Green L, Sivapalaratnam S, Pasi KJ, MacCallum P. Lupus anticoagulant and abnormal coagulation tests in patients with Covid-19. New Engl J Med 2020;383:288-90. DOI: 10.1056/NEJMc2013656

Supervision

MD(Res) Ruchika Kohli, British Society for Haematology Early Stage Grant, Evaluation of pharmacological thromboprophylaxis in renal transplantation: evidence, current practice, and haemostatic changes.