Dr Elisa Corsiero

Profile

ORCID iD: 0000-0003-2092-6778 

I am a Senior Lecturer at the Centre for Experimental Medicine & Rheumatology in the Immuno-Rheumatology group led by Prof Michele Bombardieri. I graduated from University of Milan (Italy) with an MSc in Industrial Biotechnology. In 2009, I joined the group of Prof Pitzalis and Prof Bombardieri in London for my PhD which I completed in 2013 with a thesis entitled: “Characterization of peripheral and lesional single B cell autoreactivity in patients with Sjögren’s syndrome and rheumatoid arthritis”. In 2014, I was awarded an Arthritis Research UK Foundation Fellowship which I completed in 2018. In November 2019, I was awarded with a competitive Career Development Fellowship from Versus Arthritis, which is funding my research. In 2022, I was awarded as PI a Large Project Grant from the Barts Charity on the generation of human antibodies specific to Sjögren’s Syndrome (SS) diseased tissue specific neoepitops for development of novel diagnostic and targeted immunotherapies.

Research

Group members

Post-doctoral Fellows: Dr Lucas Jagemann
PhD Students: Dr Mattia Caliste, Miss Mareike Werle
Visiting Research Fellows: Miss Nia Sciucca

Summary

My major research interests focus on the elucidation of the cellular and molecular mechanisms regulating autoreactive B cell activation, breach of self-tolerance and perpetuation of autoimmunity in Sjögren’s syndrome and rheumatoid arthritis. In particular, my research is focused on characterizing the fine specificity and function of monoclonal antibodies derived from single B cells and from antibody phage display technology in patients with rheumatic autoimmune diseases and cancer.

Point of contact for Biacore 1K+ SPR Instrument – Booking: iLab Centre for Experimental Medicine & Rheumatology.

Key Publications

1. High-throughput sequencing of IgH gene in minor salivary glands from Sjögren’s syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures. Carlotti E, Murray-Brown W, Blighe K, Floyd JAB, Caliste M, Astorri E, Sutcliffe N, Tappuni AR, Pitzalis C, Corsiero E* and Bombardieri M*. Clin Exp Rheumatol 2022 Vol. 40 Issue 12 Pages 2363-2372 (*co-last senior author). 
2. Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression. Meednu, Rangel-Moreno, Zhang, Escalera-Rivera, Corsiero E, Prediletto, DiCarlo, Goodman, Donlin, Raychauduri, Bombardieri, Pitzalis, Orange, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; A McDavid, J H Anolik. Cell Rep. 2022; 39(5):110766.
3. Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients. M. Vomero, M. Caliste, C. Barbati, M. Speziali, A. I. Celia, F. Ucci, C. Ciancarella, E. Putro, T. Colasanti, G. Buoncuore, Corsiero E, M. Bombardieri, F. R. Spinelli, F. Ceccarelli, F. Conti and C. Alessandri (2022). Front Pharmacol 2022 Vol. 13 Pages 852802.
4. Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution. Colombo F, Corsiero E, Lewis M J, Pitzalis C (2021). Sci Rep 2021 Vol. 11 Issue 1 Pages 11773.
5. Heavy and light chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity towards NETs antigens in RA synovial B-cell clones. Corsiero, Carlotti, Jagemann, Perretti, Pitzalis and Bombardieri. Journal of Immunology, 2020 Mar 27.
6. B cells in the formation of tertiary lymphoid organs in autoimmunity, transplantation and tumorigenesis. Corsiero, Delvecchio, Bombardieri, Pitzalis. Curr Opin Immunol, 2019.
7. Generation of recombinant monoclonal antibodies from single B cells isolated from synovial tissue of rheumatoid arthritis patients. Corsiero, Jagemann, Bombardieri and Pitzalis. Methods Mol Biol, 2018.
8. Characterization of a synovial B cell-derived recombinant monoclonal antibody targeting stromal calreticulin in the rheumatoid joints. Corsiero, Jagemann, Perretti, Pitzalis and Bombardieri. Journal of Immunology, July 2018.
9. NETosis as Source of Autoantigens in Rheumatoid Arthritis. Corsiero, Pratesi, Prediletto, Bombardieri, Migliorini. Front Immunol, 2016.
10. Ectopic Lymphoid Structures: Powerhouse of Autoimmunity. Corsiero, Nerviani, Bombardieri, Pitzalis. Front. Immunol, 2016.
11. Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs. Corsiero, Bombardieri, Carlotti, Pratesi, Robinson, Migliorini, and Pitzalis. Ann Rheum Dis, 2016.
12. Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Headland, Jones, Norling, Kim, Souza, Corsiero, Gil, Nerviani, Dell'Accio, Pitzalis, Oliani, Jan, Perretti. Sci Transl Med, 2015.
13. Accumulation of Self-Reactive Naive and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome. Corsiero, Sutcliffe, Pitzalis, Bombardieri. Plos One, 2014.
14. Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis. Corsiero, Pitzalis and Bombardieri. Drug Discovery Today, 2014.
15. Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases. Corsiero, Bombardieri, Manzo, Bugatti, Uguccioni and Pitzalis, Immunology Letters, 2012.

Collaborators

Internal

Prof Michele Bombardieri; Prof Ahuva Nissim

External

Prof Paola Migliorini (Pisa University); Dr Mariangela Figini (IRCSS Instituto Tumori, Milan)

Teaching

I am actively engaged in undergraduate teaching including: i) Module Lead of the BMD375 module and Lecturer for BMD171 of the BSc degree in Pharmacology & Innovative Therapeutics; ii) Tutor of BSc Pharmacology students; iii) PBL Facilitator.

Disclosures

No disclosures.