Dr Robin N. Poston

Profile

Robin Poston is an academic pathologist who studied Medicine at Cambridge University and the Middlesex Hospital, London, and spent many years in the Medical School at Guy’s Hospital, (now part of King’s College London). He focused on atherosclerosis research, and made the original observations indicating that adhesion molecules attract blood leukocytes to human atherosclerotic plaques.  

Robert Poston is a Principal Investigator at the Centre for Microvascular Research.

Research

Binding and oxidation of LDL by the endothelium in atherosclerosis

Although the oxidation of LDL has been classically associated with macrophages, endothelial cells are also capable, and the important function of ox-LDL is in targeting and activating endothelial cells towards atherosclerotic processes. With support from the William Harvey Research Foundation, we have new evidence of the association of ox-LDL with the endothelium, in human atherosclerosis, in cultured endothelial cells, and in the periphery in an animal model of hyperlipidaemia. We wish to find the mechanisms of this oxidation, and determine its role in atherosclerosis. A research grant application is currently being submitted to the British Heart Foundation by Dr Poston and Professor Nourshargh.  

Publications

• Poston RN, Chughtai J, Ujkaj D et al. (publicationYear). Monocytic Cell Adhesion to Oxidised Ligands: Relevance to Cardiovascular Disease. nameOfConference

  
  

  DOI: 10.3390/biomedicines10123083

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/83452
• Karamanavi E, McVey DG, van der Laan SW et al. (2022). The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis. nameOfConference

  
  

  DOI: 10.1161/circresaha.122.321146

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/83640
• Barkaway A, Rolas L, Joulia R et al. (2021). Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. nameOfConference

  
  

  DOI: 10.1016/j.immuni.2021.04.025

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/72327
• An W, Luong LA, Bowden NP et al. (2022). Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling. nameOfConference

  
  

  DOI: 10.1093/cvr/cvab056

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/70862
• Karamanavi E, Mcvey DG, Van Der Laan SW et al. (2020). The FES gene, located at the chromosome 15Q21.6 coronary-artery-disease locus, modulates atherosclerotic plaque vulnerability. nameOfConference

  
  

  DOI: 10.1016/j.atherosclerosis.2020.10.070

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/83759
• Heister PM, Poston RN (2020). Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19. nameOfConference

  
  

  DOI: 10.1002/prp2.653

  
  

  QMRO: qmroHref
• Yang X, Yang W, McVey DG et al. (2020). FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease–Associated Genetic Variant and Influences Monocyte Transendothelial Migration. nameOfConference

  
  

  DOI: 10.1161/jaha.119.014333

  
  

  QMRO: qmroHref
• Read JE, Luo D, Chowdhury TT et al. (2020). Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production. nameOfConference

  
  

  DOI: 10.1039/c9nr10329e

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64585
• Arokiasamy S, King R, Boulaghrasse H et al. (2019). Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo. nameOfConference

  
  

  DOI: 10.3389/fimmu.2019.02316

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/60002
• Poston RN (2019). Atherosclerosis: integration of its pathogenesis as a self-perpetuating propagating inflammation: a review.. nameOfConference

  
  

  DOI: 10.1097/xce.0000000000000172

  
  

  QMRO: qmroHref
• Luo D, Poston RN, Gould DJ et al. (2019). Magnetically targetable microcapsules display subtle changes in permeability and drug release in response to a biologically compatible low frequency alternating magnetic field. nameOfConference

  
  

  DOI: 10.1016/j.msec.2018.10.031

  
  

  QMRO: qmroHref
• Tarvala U, Poston RN (2018). P31 VARIATION OF VON-WILLEBRAND FACTOR EXPRESSION IN THE ENDOTHELIUM OF HUMAN CORONARY ATHEROSCLEROTIC PLAQUES: IMPLICATIONS FOR THROMBOSIS. nameOfConference

  
  

  DOI: 10.1093/cvr/cvy216.034

  
  

  QMRO: qmroHref
• Tarvala U, Matary RE, Nightingale T et al. (2018). Decrease in Von-Willebrand factor protein in the endothelium of human coronary atherosclerotic plaques: Possible mechanisms and role in thrombosis. nameOfConference

  
  

  DOI: 10.1016/j.atherosclerosis.2018.06.257

  
  

  QMRO: qmroHref
• Gai M, Kurochkin MA, Li D et al. (2018). In-situ NIR-laser mediated bioactive substance delivery to single cell for EGFP expression based on biocompatible microchamber-arrays.. nameOfConference

  
  

  DOI: 10.1016/j.jconrel.2018.02.044

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/39107
• Tarvala U, Poston RN (2018). Variation of von-Willebrand Factor Expression in the Endothelium of Human Coronary Atherosclerotic Plaques: Implications for Thrombosis. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Chan K, Pu X, Sandesara P et al. (2017). Genetic Variation at the ADAMTS7 Locus is Associated With Reduced Severity of Coronary Artery Disease. nameOfConference

  
  

  DOI: 10.1161/jaha.117.006928

  
  

  QMRO: qmroHref
• Chan K, Patel R, Pu X et al. (2017). Genetic variation at ADAMTS7 and severity of coronary artery disease. nameOfConference

  
  

  DOI: 10.1016/s0140-6736(17)30427-0

  
  

  QMRO: qmroHref
• Yang W, Ng FL, Chan K et al. (2016). Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction. nameOfConference

  
  

  DOI: 10.1371/journal.pgen.1006127

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13881
• Nasr H, Torsney E, Poston RN et al. (2015). Investigating the Effect of a Single Infusion of Reconstituted High-Density Lipoprotein in Patients with Symptomatic Carotid Plaques. nameOfConference

  
  

  DOI: 10.1016/j.avsg.2015.04.084

  
  

  QMRO: qmroHref
• Chan K, Patel R, Pu X et al. (2015). 189 Genetic Variation in ADAMTS7 is Associated with Severity of Coronary Artery Disease. nameOfConference

  
  

  DOI: 10.1136/heartjnl-2015-308066.189

  
  

  QMRO: qmroHref
• Pu X, Xiao Q, Kiechl S et al. (2013). YIA3: ADAMTS7 CLEAVAGE AND VASCULAR SMOOTH MUSCLE CELL MIGRATION IS AFFECTED BY A CORONARY ARTERY DISEASE ASSOCIATED VARIANT. nameOfConference

  
  

  DOI: 10.1136/heartjnl-2013-304019.270

  
  

  QMRO: qmroHref
• Pu X, Xiao Q, Kiechl S et al. (2013). ADAMTS7 Cleavage and Vascular Smooth Muscle Cell Migration Is Affected by a Coronary-Artery-Disease-Associated Variant. nameOfConference

  
  

  DOI: 10.1016/j.ajhg.2013.01.012

  
  

  QMRO: qmroHref
• Motterle A, Pu X, Wood H et al. (2012). Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells. nameOfConference

  
  

  DOI: 10.1093/hmg/dds224

  
  

  QMRO: qmroHref
• Foster PA, Costa SKP, Poston R et al. (2003). Endothelial cells play an essential role in the thermal hyperalgesia induced by nerve growth factor. nameOfConference

  
  

  DOI: 10.1096/fj.02-1000fje

  
  

  QMRO: qmroHref

Collaborators

Internal

• Professor Carol Shoulders (WHRI)
• Dr Dianne Cooper (WHRI)
• Dr Egle Solito (WHRI)
• Professor Shu Ye (WHRI)
• Professor Graham Hitman (Blizard Institute)

External

• Dr David Leake (University of Reading)